{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T14:24:32Z","timestamp":1791383072202,"version":"4.3.3"},"reference-count":46,"publisher":"National Academy of Sciences","issue":"4","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,1,24]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Tuberculosis (TB) is an immunopathology, mostly of the lung, due to an overexuberant immune response to the bacterial pathogen\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    . Here, we demonstrate in vitro and in vivo that dendritic cell (DC) immunoreceptor (DCIR), a C-type lectin receptor expressed by DCs, modulates immunity to TB by sustaining type I IFN signaling in DCs. These findings were generalized beyond TB, in a model of in vivo antigen-presentation assay unrelated to\n                    <jats:italic>M. tuberculosis<\/jats:italic>\n                    , suggesting that they may extend to other pathologies, such as viral infections or autoimmune disorders. Thus, modulating DCIR activity may help to develop type I IFN-targeting therapies for a large repertoire of inflammatory disorders, including TB.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1613254114","type":"journal-article","created":{"date-parts":[[2017,1,9]],"date-time":"2017-01-09T22:00:32Z","timestamp":1483999232000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":81,"title":["C-type lectin receptor DCIR modulates immunity to tuberculosis by sustaining type I interferon signaling in dendritic cells"],"prefix":"10.1073","volume":"114","author":[{"given":"Anthony","family":"Troegeler","sequence":"first","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS, 31000 Toulouse, France;"},{"name":"IPBS, Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier (UPS), 31000 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Mercier","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS, 31000 Toulouse, France;"},{"name":"IPBS, Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier (UPS), 31000 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Cougoule","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS, 31000 Toulouse, France;"},{"name":"IPBS, Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier (UPS), 31000 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danilo","family":"Pietretti","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS, 31000 Toulouse, France;"},{"name":"IPBS, Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier (UPS), 31000 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Colom","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS, 31000 Toulouse, France;"},{"name":"IPBS, Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier (UPS), 31000 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine","family":"Duval","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS, 31000 Toulouse, France;"},{"name":"IPBS, Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier (UPS), 31000 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thien-Phong","family":"Vu Manh","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille\u2013Luminy, INSERM U1104, CNRS UMR7280, Aix Marseille Universit\u00e9, F-13288 Marseille Cedex 09, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florence","family":"Capilla","sequence":"additional","affiliation":[{"name":"Service d\u2019Histopathologie, INSERM\/UPS-Unit\u00e9 de service 006\/Centre R\u00e9gional d\u2019Exploration fonctionnelle et Ressources Exp\u00e9rimentales, Centre Hospitalier Universitaire Purpan, 31300 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renaud","family":"Poincloux","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS, 31000 Toulouse, France;"},{"name":"IPBS, Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier (UPS), 31000 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Pingris","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS, 31000 Toulouse, France;"},{"name":"IPBS, Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier (UPS), 31000 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Nigou","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS, 31000 Toulouse, France;"},{"name":"IPBS, Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier (UPS), 31000 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Rademann","sequence":"additional","affiliation":[{"name":"Pharmaceutical and Medicinal Chemistry, Freie Universit\u00e4t Berlin, 14195 Berlin, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Dalod","sequence":"additional","affiliation":[{"name":"Centre d\u2019Immunologie de Marseille\u2013Luminy, INSERM U1104, CNRS UMR7280, Aix Marseille Universit\u00e9, F-13288 Marseille Cedex 09, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank A. W.","family":"Verreck","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Biomedical Primate Research Centre, 2288 GJ, Rijswijk, The Netherlands;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talal","family":"Al Saati","sequence":"additional","affiliation":[{"name":"Service d\u2019Histopathologie, INSERM\/UPS-Unit\u00e9 de service 006\/Centre R\u00e9gional d\u2019Exploration fonctionnelle et Ressources Exp\u00e9rimentales, Centre Hospitalier Universitaire Purpan, 31300 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geanncarlo","family":"Lugo-Villarino","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS, 31000 Toulouse, France;"},{"name":"IPBS, Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier (UPS), 31000 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Lepenies","sequence":"additional","affiliation":[{"name":"Immunology Unit, University of Veterinary Medicine Hannover, 30559 Hannover, Germany;"},{"name":"Center for Emerging Infections and Zoonoses, University of Veterinary Medicine Hannover, 30559 Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Hudrisier","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS, 31000 Toulouse, France;"},{"name":"IPBS, Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier (UPS), 31000 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Neyrolles","sequence":"additional","affiliation":[{"name":"Institut de Pharmacologie et de Biologie Structurale (IPBS), CNRS, 31000 Toulouse, France;"},{"name":"IPBS, Universit\u00e9 de Toulouse, Universit\u00e9 Paul Sabatier (UPS), 31000 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,1,9]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev.immunol.021908.132703","article-title":"Cell-mediated immune responses in tuberculosis","volume":"27","author":"Cooper AM","year":"2009","unstructured":"AM Cooper, Cell-mediated immune responses in tuberculosis. 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