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Further, we identified the conserved stem loop structure at 3\u2032UTR of T-bet mRNA required for binding Arid5a during its action. Our study indicates the therapeutic potential of anti-agonistic agents for Arid5a in the prevention of pathological conditions of septic shock.<\/jats:p>","DOI":"10.1073\/pnas.1613307113","type":"journal-article","created":{"date-parts":[[2016,9,26]],"date-time":"2016-09-26T20:48:35Z","timestamp":1474922915000},"page":"11543-11548","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":56,"title":["Arid5a exacerbates IFN-\u03b3\u2013mediated septic shock by stabilizing T-bet mRNA"],"prefix":"10.1073","volume":"113","author":[{"given":"Mohammad Mahabub-Uz","family":"Zaman","sequence":"first","affiliation":[{"name":"Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuya","family":"Masuda","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kishan Kumar","family":"Nyati","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen Kumar","family":"Dubey","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Ripley","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaya Prakash","family":"Chalise","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuru","family":"Higa","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamza","family":"Hanieh","sequence":"additional","affiliation":[{"name":"Biological Sciences Department, College of Science, King Faisal University, Al-Ahsa 31982, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadamitsu","family":"Kishimoto","sequence":"additional","affiliation":[{"name":"Laboratory of Immune Regulation, World Premier International Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,9,26]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-011110-130327"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.11.040193.003035"},{"key":"e_1_3_3_3_2","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.4049\/jimmunol.145.9.2920","article-title":"The role of IFN-gamma in the pathology of experimental endotoxemia","volume":"145","author":"Heinzel FP","year":"1990","unstructured":"FP Heinzel, The role of IFN-gamma in the pathology of experimental endotoxemia. 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