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U.S.A."],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Resistance to antibiotics poses a serious threat in contemporary medicine. Avilamycin and evernimicin, polysaccharide antibiotics belonging to the orthosomycin family, possess inhibitory activity against multidrug-resistant pathogenic strains of\n                    <jats:italic>Enterococci<\/jats:italic>\n                    ,\n                    <jats:italic>Staphylococci<\/jats:italic>\n                    , and other\n                    <jats:italic>Streptococci<\/jats:italic>\n                    gram-positive bacteria by paralyzing ribosomes function in protein biosynthesis. The crystal structures of the large ribosomal subunit from the eubacteria\n                    <jats:italic>Deinococcus radiodurans<\/jats:italic>\n                    in complex with avilamycin and evernimicin revealed their binding sites at the entrance to the A-site tRNA accommodating corridor, thus illuminating the mechanisms of their translation inhibition. Analysis of the binding interactions of these antibiotics depicted the features enabling their species discrimination (namely, selectivity) and elucidated the various mechanisms by which pathogens use single mutations to acquire resistance to those drugs.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1614297113","type":"journal-article","created":{"date-parts":[[2016,10,19]],"date-time":"2016-10-19T23:45:25Z","timestamp":1476920725000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":25,"title":["Avilamycin and evernimicin induce structural changes in rProteins uL16 and CTC that enhance the inhibition of A-site tRNA binding"],"prefix":"10.1073","volume":"113","author":[{"given":"Miri","family":"Krupkin","sequence":"first","affiliation":[{"name":"Department of Structural Biology, Weizmann Institute, Rehovot 76100 001, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itai","family":"Wekselman","sequence":"additional","affiliation":[{"name":"Department of Structural Biology, Weizmann Institute, Rehovot 76100 001, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Matzov","sequence":"additional","affiliation":[{"name":"Department of Structural Biology, Weizmann Institute, Rehovot 76100 001, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zohar","family":"Eyal","sequence":"additional","affiliation":[{"name":"Department of Structural Biology, Weizmann Institute, Rehovot 76100 001, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Diskin Posner","sequence":"additional","affiliation":[{"name":"Department of Structural Biology, Weizmann Institute, Rehovot 76100 001, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haim","family":"Rozenberg","sequence":"additional","affiliation":[{"name":"Department of Structural Biology, Weizmann Institute, Rehovot 76100 001, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ella","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Department of Structural Biology, Weizmann Institute, Rehovot 76100 001, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Bashan","sequence":"additional","affiliation":[{"name":"Department of Structural Biology, Weizmann Institute, Rehovot 76100 001, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ada","family":"Yonath","sequence":"additional","affiliation":[{"name":"Department of Structural Biology, Weizmann Institute, Rehovot 76100 001, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,10,19]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"72S","DOI":"10.1016\/0002-9343(91)90346-Y","article-title":"Major trends in the microbial etiology of nosocomial infection","volume":"91","author":"Schaberg DR","year":"1991","unstructured":"DR Schaberg, DH Culver, RP Gaynes, Major trends in the microbial etiology of nosocomial infection. 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