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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,2,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Spreading depression is proposed to underlie migraine with aura, a type of debilitating headache for which few pharmacological treatments are available. The pain drug pregabalin has demonstrated initial promising results for the treatment of migraine in the clinic. Utilizing animal models of congenital migraine and live brain imaging, we describe the cortical and subcortical migration of the spreading depression wave. Further, pregabalin is shown to be effective at suppressing spreading depression initiation, wave speed, and subcortical propagation, and also to affect nerve cell signalling directly. Overall, the study supports the therapeutic potential of pregabalin in both noncongenital migraineurs and patients with mild congenital migraine.<\/jats:p>","DOI":"10.1073\/pnas.1614447114","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T20:40:29Z","timestamp":1487709629000},"page":"2401-2406","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":55,"title":["In vivo imaging reveals that pregabalin inhibits cortical spreading depression and propagation to subcortical brain structures"],"prefix":"10.1073","volume":"114","author":[{"given":"Stuart M.","family":"Cain","sequence":"first","affiliation":[{"name":"Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada;"},{"name":"Djavad Mowafaghian Center for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Bohnet","sequence":"additional","affiliation":[{"name":"UBC MRI Research Centre, University of British Columbia, Vancouver, BC V6T 1Z4, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"LeDue","sequence":"additional","affiliation":[{"name":"Djavad Mowafaghian Center for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew C.","family":"Yung","sequence":"additional","affiliation":[{"name":"UBC MRI Research Centre, University of British Columbia, Vancouver, BC V6T 1Z4, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esperanza","family":"Garcia","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada;"},{"name":"Djavad Mowafaghian Center for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R.","family":"Tyson","sequence":"additional","affiliation":[{"name":"Michael Smith Laboratories, University of British Columbia, Vancouver, BC V6T 1Z4, Canada;"},{"name":"Djavad Mowafaghian Center for Brain Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha R. 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