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The use of this scaffold revealed that NRF2 activation responses were muted in HD patient-derived neural stem cells, suggesting increased susceptibility of this critical renewable cell population to oxidative stress in HD brain. However, pharmacological activation of NRF2 was able to repress inflammatory responses in mouse microglia and astrocytes, the principal cellular mediators of neuroinflammation, and in blood monocytes from HD patients. Our results suggest multiple protective benefits of NRF2 activation for HD patients.<\/jats:p>","DOI":"10.1073\/pnas.1614943114","type":"journal-article","created":{"date-parts":[[2017,5,22]],"date-time":"2017-05-22T20:40:47Z","timestamp":1495485647000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":134,"title":["KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients"],"prefix":"10.1073","volume":"114","author":[{"given":"Luisa","family":"Quinti","sequence":"first","affiliation":[{"name":"Department of Neurology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharadha","family":"Dayalan Naidu","sequence":"additional","affiliation":[{"name":"Division of Cancer Research, School of Medicine, University of Dundee, Dundee DD1 9SY, Scotland, United 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