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These results provide a structural basis for the origins of secondary mutations and suggest that transient encounter complexes play a significant role in guiding protease to the Gag cleavage sites.<\/jats:p>","DOI":"10.1073\/pnas.1615342113","type":"journal-article","created":{"date-parts":[[2016,10,18]],"date-time":"2016-10-18T16:37:54Z","timestamp":1476808674000},"page":"12456-12461","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":30,"title":["Transient HIV-1 Gag\u2013protease interactions revealed by paramagnetic NMR suggest origins of compensatory drug resistance mutations"],"prefix":"10.1073","volume":"113","author":[{"given":"Lalit","family":"Deshmukh","sequence":"first","affiliation":[{"name":"Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Louis","sequence":"additional","affiliation":[{"name":"Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Ghirlando","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. 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