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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,2,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>We have tested the hypothesis that the placenta of early pregnancy might be more easily breached by the Zika virus (ZIKV) than the relatively resistant outer cells of the mature placenta. Colonies of placental lineage cells derived from embryonic stem cells, which are probably analogous to the primitive placenta at implantation, were lysed more rapidly by an African strain of ZIKV, considered relatively benign, than by an Asian strain linked to fetal brain abnormalities. We conclude that the human fetus may be most vulnerable to ZIKV very early in pregnancy and that the African strain may threaten a pregnancy more strongly than previously believed.<\/jats:p>","DOI":"10.1073\/pnas.1616097114","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T21:00:27Z","timestamp":1487019627000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":160,"title":["Vulnerability of primitive human placental trophoblast to Zika virus"],"prefix":"10.1073","volume":"114","author":[{"given":"Megan A.","family":"Sheridan","sequence":"first","affiliation":[{"name":"Bond Life Sciences Center, University of Missouri, Columbia, MO 65211;"},{"name":"Department of Biochemistry, University of Missouri, Columbia, MO 65211;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinar","family":"Yunusov","sequence":"additional","affiliation":[{"name":"Bond Life Sciences Center, University of Missouri, Columbia, MO 65211;"},{"name":"Departamento de Bioqu\u00edmica, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo, 05508-900 S\u00e3o Paulo, SP, Brazil;"},{"name":"Laboratory of Gene Expression, Instituto Butantan, 05503-900 S\u00e3o Paulo, SP, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Velmurugan","family":"Balaraman","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrei P.","family":"Alexenko","sequence":"additional","affiliation":[{"name":"Bond Life Sciences Center, University of Missouri, Columbia, MO 65211;"},{"name":"Division of Animal Sciences, University of Missouri, Columbia, MO 65211;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Yabe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Women\u2019s Health, University of Missouri, Columbia, MO 65211;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Verjovski-Almeida","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Instituto de Qu\u00edmica, Universidade de S\u00e3o Paulo, 05508-900 S\u00e3o Paulo, SP, Brazil;"},{"name":"Laboratory of Gene Expression, Instituto Butantan, 05503-900 S\u00e3o Paulo, SP, Brazil;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danny J.","family":"Schust","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology, and Women\u2019s Health, University of Missouri, Columbia, MO 65211;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander W.","family":"Franz","sequence":"additional","affiliation":[{"name":"Department of Veterinary Pathobiology, University of Missouri, Columbia, MO 65211;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2969-6737","authenticated-orcid":false,"given":"Yoel","family":"Sadovsky","sequence":"additional","affiliation":[{"name":"Magee-Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15213"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Ezashi","sequence":"additional","affiliation":[{"name":"Bond Life Sciences Center, University of Missouri, Columbia, MO 65211;"},{"name":"Division of Animal Sciences, University of Missouri, Columbia, MO 65211;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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