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We identified a new conopeptide from the venom of the cone snail\n                    <jats:italic>Conus textile<\/jats:italic>\n                    that targets the proton-gated ion channel ASIC3, which detects painful acidosis. This peptide belongs to the subgroup of cono-RFamides and potentiates ASIC3 currents, thereby increasing the excitability of nociceptors. Injection of the cono-RFamide in mice muscle enhanced acid-induced muscle pain. Our results thus identify ASIC3 as the first molecular target of cono-RFamides. These findings underline the role of ASIC3 in pain perception and the importance of nontoxic venom components.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1616232114","type":"journal-article","created":{"date-parts":[[2017,4,10]],"date-time":"2017-04-10T20:55:27Z","timestamp":1491857727000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":57,"title":["Identification of a cono-RFamide from the venom of\n                    <i>Conus textile<\/i>\n                    that targets ASIC3 and enhances muscle pain"],"prefix":"10.1073","volume":"114","author":[{"given":"Catharina","family":"Reimers","sequence":"first","affiliation":[{"name":"Institute of Physiology, Rheinisch-Westfaelische Technische Hochschule (RWTH) Aachen University, 52074 Aachen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Han","family":"Lee","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Sciences, 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