{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T19:13:56Z","timestamp":1789758836907,"version":"4.0.1"},"reference-count":43,"publisher":"National Academy of Sciences","issue":"16","license":[{"start":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:00:00Z","timestamp":1506988800000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["DK097105"],"award-info":[{"award-number":["DK097105"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,4,18]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Renal calcium reabsorption is a critical process for maintaining systemic calcium homeostasis. Although the role of parathyroid hormone (PTH) in the regulation of transcellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    reabsorption in distal convoluted tubules is well understood, its potential role in controlling the paracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    transport in the thick ascending limb of Henle (TAL) has not been investigated. We now present data demonstrating that PTH\/PTHrP receptor (PTH1R) signaling directly and indirectly controls the levels of Claudin14 (CLDN14), a tight-junction protein responsible for paracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    transport in the TAL. Our findings suggest that down-regulation of Claudin14 could provide a potential treatment option to correct urinary Ca\n                    <jats:sup>2+<\/jats:sup>\n                    loss, particularly in patients with hypoparathyroidism.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1616733114","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T20:43:34Z","timestamp":1491252214000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":73,"title":["Parathyroid hormone controls paracellular Ca\n                    <sup>2+<\/sup>\n                    transport in the thick ascending limb by regulating the tight-junction protein Claudin14"],"prefix":"10.1073","volume":"114","author":[{"given":"Tadatoshi","family":"Sato","sequence":"first","affiliation":[{"name":"Division of Bone and Mineral Research, Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 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Dental Medicine, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-ichi","family":"Hanai","sequence":"additional","affiliation":[{"name":"Division of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115;"},{"name":"Division of Nephrology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jovana","family":"Kaludjerovic","sequence":"additional","affiliation":[{"name":"Division of Bone and Mineral Research, Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Densmore","sequence":"additional","affiliation":[{"name":"Division of Bone and Mineral Research, Oral Medicine, Infection and Immunity, Harvard School of 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