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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,2,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The hypothalamo\u2013pituitary axis controls a wide range of homeostatic processes, including growth, stress, and reproduction. Despite this fact, the hypothalamic neuron firing patterns that lead to slowly evolving pituitary hormone rhythms remain enigmatic. Here, we used in vivo amperometric recordings in freely behaving mice to investigate how tuberoinfundibular neurons release dopamine (DA) at the median eminence (ME) to control pituitary prolactin secretion. Using this approach, we show that DA release occurs as multiple locally generated and time-scaled secretory events, which are integrated over a range of minutes across the ME. These results provide a broad physiological mechanism for the dialogue that occurs between the brain and pituitary to dictate hormone rhythms over multiple timescales, from ultradian to seasonal.<\/jats:p>","DOI":"10.1073\/pnas.1616864114","type":"journal-article","created":{"date-parts":[[2017,2,13]],"date-time":"2017-02-13T21:00:27Z","timestamp":1487019627000},"page":"2379-2382","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":23,"title":["Multiple-scale neuroendocrine signals connect brain and pituitary hormone rhythms"],"prefix":"10.1073","volume":"114","author":[{"given":"Nicola","family":"Roman\u00f2","sequence":"first","affiliation":[{"name":"Institute of Functional Genomics (IGF), CNRS, INSERM, University of Montpellier, F-34094 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Guillou","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics (IGF), CNRS, INSERM, University of Montpellier, F-34094 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8641-8568","authenticated-orcid":false,"given":"David J.","family":"Hodson","sequence":"additional","affiliation":[{"name":"Institute of Metabolism and Systems Research and Centre of Membrane Proteins and Receptors, University of Birmingham, Edgbaston B15 2TT, United Kingdom;"},{"name":"Centre for Endocrinology, Diabetes and Metabolism, Birmingham Health Partners, Birmingham B15 2TH, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agn\u00e8s O","family":"Martin","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics (IGF), CNRS, INSERM, University of Montpellier, F-34094 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Mollard","sequence":"additional","affiliation":[{"name":"Institute of Functional Genomics (IGF), CNRS, INSERM, University of Montpellier, F-34094 Montpellier, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,2,13]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.10.002"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-15-0213"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.70"},{"key":"e_1_3_3_4_2","article-title":"An updated view of hypothalamic-vascular-pituitary unit function and plasticity","author":"Le Tissier P","year":"2016","unstructured":"P Le Tissier, , An updated view of hypothalamic-vascular-pituitary unit function and plasticity. 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