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U.S.A."],"published-print":{"date-parts":[[2017,1,10]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Influenza virus is an important human pathogen. The circulating strains of influenza virus are constantly mutating and are acquiring resistance to all approved drugs. Therefore, development of influenza therapeutics against novel targets is urgently required. The hemagglutinin envelope glycoprotein (HA) is a promising target for small-molecule design. However, Arbidol is the only available antiviral drug that targets the HA. The absence of structural information on drug\u2013HA complexes has hindered further therapeutic development efforts against this viral pathogen. Here, we report crystal structures of Arbidol in complex with influenza HAs. This structural information advances our understanding of how small molecules, such as Arbidol, can function as influenza fusion inhibitors and can be used for development of broad-spectrum, small-molecule therapeutics.<\/jats:p>","DOI":"10.1073\/pnas.1617020114","type":"journal-article","created":{"date-parts":[[2016,12,21]],"date-time":"2016-12-21T21:35:46Z","timestamp":1482356146000},"page":"206-214","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":380,"title":["Structural basis of influenza virus fusion inhibition by the antiviral drug Arbidol"],"prefix":"10.1073","volume":"114","author":[{"given":"Rameshwar U.","family":"Kadam","sequence":"first","affiliation":[{"name":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A.","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037;"},{"name":"The Skaggs Institute for Chemical Biology, The Scripps Research Institute, La Jolla, CA 92037"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2016,12,21]]},"reference":[{"key":"e_1_3_4_1_2","first-page":"223","article-title":"The chronicle of influenza epidemics","volume":"13","author":"Beveridge WI","year":"1991","unstructured":"WI Beveridge, The chronicle of influenza epidemics. 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