{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T20:30:28Z","timestamp":1792009828296,"version":"4.4.0"},"reference-count":42,"publisher":"National Academy of Sciences","issue":"15","license":[{"start":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T00:00:00Z","timestamp":1490745600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["107613\/Z\/15\/Z"],"award-info":[{"award-number":["107613\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"HHS | National Institutes of Health","doi-asserted-by":"publisher","award":["P01GM095467"],"award-info":[{"award-number":["P01GM095467"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,4,11]]},"abstract":"<jats:p>\n                    The resolution of inflammation is an active process orchestrated by specialized proresolving lipid mediators (SPM) that limit the host response within the affected tissue; failure of effective resolution may lead to tissue injury. Because persistence of inflammatory signals is a main feature of chronic inflammatory conditions, including inflammatory bowel diseases (IBDs), herein we investigate expression and functions of SPM in intestinal inflammation. Targeted liquid chromatography-tandem mass spectrometry-based metabololipidomics was used to identify SPMs from n-3 polyunsaturated fatty acids in human IBD colon biopsies, quantifying a significant up-regulation of the resolvin and protectin pathway compared with normal gut tissue. Systemic treatment with protectin (PD)1\n                    <jats:sub>n-3 DPA<\/jats:sub>\n                    or resolvin (Rv)D5\n                    <jats:sub>n-3 DPA<\/jats:sub>\n                    protected against colitis and intestinal ischemia\/reperfusion-induced inflammation in mice. Inhibition of 15-lipoxygenase activity reduced PD1\n                    <jats:sub>n-3 DPA<\/jats:sub>\n                    and augmented intestinal inflammation in experimental colitis. Intravital microscopy of mouse mesenteric venules demonstrated that PD1\n                    <jats:sub>n-3 DPA<\/jats:sub>\n                    and RvD5\n                    <jats:sub>n-3 DPA<\/jats:sub>\n                    decreased the extent of leukocyte adhesion and emigration following ischemia-reperfusion. These data were translated by assessing human neutrophil\u2013endothelial interactions under flow: PD1\n                    <jats:sub>n-3 DPA<\/jats:sub>\n                    and RvD5\n                    <jats:sub>n-3 DPA<\/jats:sub>\n                    reduced cell adhesion onto TNF-\u03b1\u2013activated human endothelial monolayers. In conclusion, we propose that innovative therapies based on n-3 DPA-derived mediators could be developed to enable antiinflammatory and tissue protective effects in inflammatory pathologies of the gut.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1617290114","type":"journal-article","created":{"date-parts":[[2017,3,29]],"date-time":"2017-03-29T21:10:31Z","timestamp":1490821831000},"page":"3963-3968","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":168,"title":["Protectin D1\n                    <sub>n-3 DPA<\/sub>\n                    and resolvin D5\n                    <sub>n-3 DPA<\/sub>\n                    are effectors of intestinal protection"],"prefix":"10.1073","volume":"114","author":[{"given":"Thomas","family":"Gobbetti","sequence":"first","affiliation":[{"name":"The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesmond","family":"Dalli","sequence":"additional","affiliation":[{"name":"The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom;"},{"name":"Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain A.","family":"Colas","sequence":"additional","affiliation":[{"name":"The William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London EC1M 6BQ, United Kingdom;"},{"name":"Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston 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Digestive Diseases, Pole Digestif, Centre Hospitalier Universitaire (CHU), 31059 Toulouse, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Vergnolle","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Sant\u00e9 Digestive (IRSD), Universit\u00e9 de Toulouse, 31300 Toulouse, France;"},{"name":"Unit 1220, INSERM, 31300 Toulouse, France;"},{"name":"Unit 1416, Institut National de la Recherche Agronomique (INRA), 31300 Toulouse, France;"},{"name":"\u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse (ENVT), 31300 Toulouse, France;"},{"name":"Universit\u00e9 Paul Sabatier (UPS), 31300 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Deraison","sequence":"additional","affiliation":[{"name":"Institut de Recherche en Sant\u00e9 Digestive (IRSD), Universit\u00e9 de Toulouse, 31300 Toulouse, France;"},{"name":"Unit 1220, INSERM, 31300 Toulouse, France;"},{"name":"Unit 1416, Institut National de la Recherche Agronomique (INRA), 31300 Toulouse, France;"},{"name":"\u00c9cole Nationale V\u00e9t\u00e9rinaire de Toulouse (ENVT), 31300 Toulouse, France;"},{"name":"Universit\u00e9 Paul Sabatier (UPS), 31300 Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trond V.","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, School of Pharmacy, University of Oslo, N-0316 Oslo, Norway;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles N.","family":"Serhan","sequence":"additional","affiliation":[{"name":"Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women\u2019s Hospital and Harvard Medical School, Boston MA 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