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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,7,18]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Sudden infant death syndrome (SIDS), the leading cause of postneonatal infant mortality, is defined as the sudden death of an infant less than 1 y of age that remains unexplained after a complete autopsy and death scene investigation. Although SIDS has been associated with deficiencies in central (brainstem) serotonin (5-hydroxytryptamine, 5-HT), there are no known peripheral biomarkers for SIDS. Here we demonstrate increased serum serotonin levels in a subset (31%) of SIDS infants compared with control infants. These findings suggest the potential of a high serum serotonin level as a forensic biomarker at autopsy to differentiate SIDS deaths with serotonergic defects from other causes of sudden death and, importantly, as evidence of a peripheral 5-HT abnormality in SIDS.<\/jats:p>","DOI":"10.1073\/pnas.1617374114","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T20:50:19Z","timestamp":1499115019000},"page":"7695-7700","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":65,"title":["High serum serotonin in sudden infant death syndrome"],"prefix":"10.1073","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4909-9585","authenticated-orcid":false,"given":"Robin L.","family":"Haynes","sequence":"first","affiliation":[{"name":"Department of Pathology, Boston Children\u2019s Hospital and Harvard Medical School, Boston, MA 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