{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T07:51:13Z","timestamp":1790841073295,"version":"4.1.0"},"reference-count":65,"publisher":"National Academy of Sciences","issue":"9","license":[{"start":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T00:00:00Z","timestamp":1502236800000},"content-version":"vor","delay-in-days":181,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"crossref","award":["SPP1608"],"award-info":[{"award-number":["SPP1608"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Bernstain Center for Computational Neuroscience","award":["01GQ1005A"],"award-info":[{"award-number":["01GQ1005A"]}]},{"name":"Flemish National Fund for Scientific Research","award":["KAN 1505013N"],"award-info":[{"award-number":["KAN 1505013N"]}]},{"DOI":"10.13039\/501100009882","name":"Regione Lombardia","doi-asserted-by":"crossref","award":["#1137-2010"],"award-info":[{"award-number":["#1137-2010"]}],"id":[{"id":"10.13039\/501100009882","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,2,28]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels mediate excitation-secretion coupling and show little inactivation at sensory ribbon synapses, enabling reliable synaptic information transfer during sustained stimulation. Studies of Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -channel complexes in HEK293 cells indicated that Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -binding proteins (CaBPs) antagonize their calmodulin-dependent inactivation. Although human mutations affecting\n                    <jats:italic>CABP2<\/jats:italic>\n                    were shown to cause hearing impairment, the role of CaBP2 in auditory function and the precise disease mechanism remained enigmatic. Here, we disrupted\n                    <jats:italic>CaBP2<\/jats:italic>\n                    in mice and showed that CaBP2 is required for sound encoding at inner hair cell synapses, likely by suppressing Ca\n                    <jats:sup>2+<\/jats:sup>\n                    -channel inactivation. We propose that the number of activatable Ca\n                    <jats:sup>2+<\/jats:sup>\n                    channels at the active zone is reduced when CaBP2 is lacking, as is likely the case with the newly described human\n                    <jats:italic>CABP2<\/jats:italic>\n                    mutation.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1617533114","type":"journal-article","created":{"date-parts":[[2017,2,9]],"date-time":"2017-02-09T21:20:14Z","timestamp":1486675214000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":62,"title":["Ca\n                    <sup>2+<\/sup>\n                    -binding protein 2 inhibits Ca\n                    <sup>2+<\/sup>\n                    -channel inactivation in mouse inner hair cells"],"prefix":"10.1073","volume":"114","author":[{"given":"Maria Magdalena","family":"Picher","sequence":"first","affiliation":[{"name":"Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Goettingen, 37099 Goettingen, Germany;"},{"name":"Goettingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences, University of Goettingen, 37077 Goettingen, Germany;"},{"name":"Bernstein Center for Computational Neuroscience, University of Goettingen, 37077 Goettingen, Germany;"},{"name":"Synaptic Nanophysiology Group, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gehrt","sequence":"additional","affiliation":[{"name":"Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Goettingen, 37099 Goettingen, Germany;"},{"name":"Auditory Systems Physiology Group, InnerEarLab, Department of Otolaryngology, University of Goettingen Medical Center, 37075 Goettingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Meese","sequence":"additional","affiliation":[{"name":"Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Goettingen, 37099 Goettingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Ivanovic","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Experimental Medicine, 37075 Goettingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Friederike","family":"Predoehl","sequence":"additional","affiliation":[{"name":"Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Goettingen, 37099 Goettingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SangYong","family":"Jung","sequence":"additional","affiliation":[{"name":"Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Goettingen, 37099 Goettingen, Germany;"},{"name":"Synaptic Nanophysiology Group, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;"},{"name":"Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University of Goettingen, 37075 Goettingen, Germany;"},{"name":"Neuro Modulation and Neuro Circuitry Group, Biomedical Sciences Institutes, Singapore Bioimaging Consortium, Biomedical Sciences Institutes, 138667 Singapore;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Schrauwen","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of Antwerp, 2610 Antwerp, Belgium;"},{"name":"Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto Giulio","family":"Dragonetti","sequence":"additional","affiliation":[{"name":"Otorhinolaryngology, Department of Surgery, Niguarda Ca\u2019 Granda Metropolitan Hospital, 20162 Milan, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Colombo","sequence":"additional","affiliation":[{"name":"Center for the Study of Rare Hereditary Diseases, Niguarda Ca\u2019 Granda Metropolitan Hospital, 20162 Milan, Italy;"},{"name":"Institute of Clinical Biochemistry, Catholic University of the Sacred Heart, 00198 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Van Camp","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of Antwerp, 2610 Antwerp, Belgium;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicola","family":"Strenzke","sequence":"additional","affiliation":[{"name":"Auditory Systems Physiology Group, InnerEarLab, Department of Otolaryngology, University of Goettingen Medical Center, 37075 Goettingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Moser","sequence":"additional","affiliation":[{"name":"Institute for Auditory Neuroscience and InnerEarLab, University Medical Center Goettingen, 37099 Goettingen, Germany;"},{"name":"Goettingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences, University of Goettingen, 37077 Goettingen, Germany;"},{"name":"Bernstein Center for Computational Neuroscience, University of Goettingen, 37077 Goettingen, Germany;"},{"name":"Synaptic Nanophysiology Group, Max Planck Institute for Biophysical Chemistry, 37077 Goettingen, Germany;"},{"name":"Max Planck Institute for Experimental Medicine, 37075 Goettingen, Germany;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,2,9]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-061010-113705"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-014-2102-7"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-34-10832.2003"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-003-4020-3"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)00013-1"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1577-09.2009"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3468-14.2016"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3411-05.2005"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2004.074740"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101469200"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2803"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1983.sp014668"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2002.87.6.2734"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/20194"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80709-6"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01174.2007"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4990-13.2014"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.142307"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3236-06.2006"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.269951"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M802254200"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.265207"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0705756104"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0514-09.2009"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.2.883"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1978.sp012228"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.2.1247"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.6228"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-005-1419-1"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.102006299"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1196-05.2005"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(95)00173-5"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/147342202320883551"},{"key":"e_1_3_3_34_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0147495"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2012.08.018"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn1320"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2845-09.2009"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31718"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.12.5860"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2016.10"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature03418"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1416424112"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00574.2004"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2010.01593.x"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1605737113"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2015.00309"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.4161\/chan.3.5.9774"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2010.03.011"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1417207112"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2895"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2013.254367"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn805"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2093-06.2006"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3311-15.2016"},{"key":"e_1_3_3_55_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2010.09.012"},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2013.06.024"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1529\/biophysj.104.045559"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1085\/jgp.200910309"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1672-2930(12)50022-X"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.1002\/humu.10274"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.08.027"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10163"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0752-12.2012"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.10.027"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3491-12.2013"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1617533114","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1617533114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T02:10:17Z","timestamp":1649815817000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1617533114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,2,9]]},"references-count":65,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,2,28]]}},"alternative-id":["10.1073\/pnas.1617533114"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1617533114","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,2,9]]},"assertion":[{"value":"2017-02-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}