{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T05:19:05Z","timestamp":1790745545557,"version":"4.1.0"},"reference-count":34,"publisher":"National Academy of Sciences","issue":"52","license":[{"start":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T00:00:00Z","timestamp":1481500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Gouvernement du Canada | Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP-125884"],"award-info":[{"award-number":["MOP-125884"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005189","name":"Leukemia and Lymphoma Society","doi-asserted-by":"publisher","award":["6239-13"],"award-info":[{"award-number":["6239-13"]}],"id":[{"id":"10.13039\/100005189","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,12,27]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Mutations in isocitrate dehydrogenase (\n                    <jats:italic>IDH<\/jats:italic>\n                    )\n                    <jats:italic>1<\/jats:italic>\n                    and\n                    <jats:italic>IDH2<\/jats:italic>\n                    contribute to malignant progression by producing the oncometabolite 2HG. In myeloid disorders, mutations at three positions in these genes are commonly observed, but in angioimmunoblastic T-cell lymphoma (AITL),\n                    <jats:italic>IDH<\/jats:italic>\n                    mutations are restricted to IDH2 arginine (R) 172. The complex microenvironment of AITL, where malignant T cells comprise a minority of the tumor, has made it difficult to evaluate the role of this mutation. Here, we provide clinical data showing that mutant IDH2 expression is restricted to malignant T cells and that 2HG may be a useful biomarker in AITL. In addition, using conditional knock-in mouse models, we find that only mutations at IDH2 R172 produce significant quantities of 2HG in lymphoid cells and alter lymphoid development.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1617929114","type":"journal-article","created":{"date-parts":[[2016,12,12]],"date-time":"2016-12-12T21:40:31Z","timestamp":1481578831000},"page":"15084-15089","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":120,"title":["The IDH2 R172K mutation associated with angioimmunoblastic T-cell lymphoma produces 2HG in T cells and impacts lymphoid development"],"prefix":"10.1073","volume":"113","author":[{"given":"Fran\u00e7ois","family":"Lemonnier","sequence":"first","affiliation":[{"name":"The Campbell Family Institute for Breast Cancer Research at Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 2C1, Canada;"},{"name":"Inserm U955, Universit\u00e9 Paris Est Cr\u00e9teil, Institut 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