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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2016,12,20]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Chronic mucocutaneous candidiasis (CMC) is defined as persistent or recurrent infections of the skin and\/or mucosae by commensal fungi of the\n                    <jats:italic>Candida<\/jats:italic>\n                    genus. It is often seen in patients with T-cell deficiencies, whether inherited or acquired, who typically suffer from multiple infectious diseases. Rare patients are otherwise healthy and display isolated CMC, which often segregates as a Mendelian trait. In 2011, we described the first genetic cause of isolated CMC, with autosomal recessive (AR), complete IL-17 receptor A (IL-17RA) deficiency, in a single patient. We report here 21 patients from 12 unrelated kindreds, homozygous for 12 different mutant alleles that underlie AR IL-17RA deficiency. All patients have isolated CMC and their cells do not respond to IL-17A, -17F, and -17E\/IL-25.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1618300114","type":"journal-article","created":{"date-parts":[[2016,12,7]],"date-time":"2016-12-07T22:30:25Z","timestamp":1481149825000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":159,"title":["Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency"],"prefix":"10.1073","volume":"113","author":[{"given":"Romain","family":"L\u00e9vy","sequence":"first","affiliation":[{"name":"Laboratory of Human Genetics of Infectious Diseases, Necker Branch, INSERM UMR 1163, 75015 Paris, France;"},{"name":"Imagine Institute, Paris Descartes University, 75015 Paris, France;"},{"name":"St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY 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