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U.S.A."],"published-print":{"date-parts":[[2017,2,14]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Our findings demonstrate a function for Down syndrome cell adhesion molecule (DSCAM) in the embryonic development of the mouse visual system. We found that DSCAM promotes fasciculation and growth of axons in the developing mouse optic pathway, at least in part, through homotypic interactions. We also found that shed DSCAM can act independently of direct cell\u2013cell contact to provide growth-promoting signals. Because the\n                    <jats:italic>Dscam<\/jats:italic>\n                    mutant phenotypes are mediated in a dose-dependent manner, these results are potentially relevant to human Down syndrome, in which\n                    <jats:italic>Dscam<\/jats:italic>\n                    is overexpressed as a result of trisomy of chromosome 21, and fragile-X syndrome, in which\n                    <jats:italic>Dscam<\/jats:italic>\n                    is overexpressed because of misregulation of\n                    <jats:italic>Dscam<\/jats:italic>\n                    mRNA.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1618606114","type":"journal-article","created":{"date-parts":[[2017,1,30]],"date-time":"2017-01-30T21:50:29Z","timestamp":1485813029000},"page":"1702-1707","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":62,"title":["DSCAM promotes axon fasciculation and growth in the developing optic pathway"],"prefix":"10.1073","volume":"114","author":[{"given":"Freyja M.","family":"Bruce","sequence":"first","affiliation":[{"name":"School of Medicine, Medical Sciences, and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Brown","sequence":"additional","affiliation":[{"name":"School of Medicine, Medical Sciences, and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan N.","family":"Smith","sequence":"additional","affiliation":[{"name":"School of Medicine, Medical Sciences, and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter G.","family":"Fuerst","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Idaho, Moscow, ID 83844;"},{"name":"Washington, Wyoming, Alaska, Montana, and Idaho (WWAMI) Medical Education Program, University of Idaho, Moscow, ID 83844"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynda","family":"Erskine","sequence":"additional","affiliation":[{"name":"School of Medicine, Medical Sciences, and Nutrition, Institute of Medical Sciences, University of Aberdeen, Aberdeen AB25 2ZD, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,1,30]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1177\/1759091414562107"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.cellbio.24.110707.175250"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/bies.201400222"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1752909"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.09.027"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2011.10.028"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2202-14.2015"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811083106"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2008.05.030"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(00)80373-6"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3563-11.2012"},{"key":"e_1_3_3_12_2","first-page":"1422","article-title":"Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina","volume":"20","author":"de Andrade GB","year":"2014","unstructured":"GB de Andrade, L Kunzelman, MM Merrill, PG Fuerst, Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina. 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