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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,5,2]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Many clinically significant human viral and bacterial pathogens use dynamin-dependent endocytosis to initiate infection or deliver toxin into host cells. Owing to the complex nature of this cellular process, the molecular mechanisms that regulate this pathway remain to be fully elucidated. Here, we use rotavirus (RV) as a model and identify drebrin as a regulatory protein that restricts the cell entry of multiple viruses. We demonstrate that genetic depletion or chemical inhibition of drebrin leads to enhanced RV infection in vitro and increased diarrhea incidence and virus shedding in vivo. Our current study provides insights into endocytosis regulation in general and highlights the potential broad application of blocking drebrin to augment the uptake of viruses and other dynamin-mediated cargo.<\/jats:p>","DOI":"10.1073\/pnas.1619266114","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T20:50:22Z","timestamp":1492462222000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":40,"title":["Drebrin restricts rotavirus entry by inhibiting dynamin-mediated endocytosis"],"prefix":"10.1073","volume":"114","author":[{"given":"Bin","family":"Li","sequence":"first","affiliation":[{"name":"Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305;"},{"name":"Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, CA 94305;"},{"name":"Palo Alto Veterans Institute of Research, VA Palo Alto Health Care System, Palo Alto, CA 94304;"},{"name":"Institute of Veterinary Medicine, Jiangsu Academy of Agricultural Sciences, Nanjing, 210014, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyuan","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305;"},{"name":"Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, CA 94305;"},{"name":"Palo Alto Veterans Institute of Research, VA Palo Alto Health Care System, Palo Alto, CA 94304;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ningguo","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305;"},{"name":"Department of Medicine, Division of Gastroenterology and Hepatology, Stanford University, Stanford, CA 94305;"},{"name":"Palo Alto Veterans Institute of Research, VA Palo Alto Health Care System, Palo 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