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This study shows that a specific gene,\n                    <jats:italic>CRKL,<\/jats:italic>\n                    which lies within the commonly deleted region at chromosome locus 22q11.2, is required for normal overall embryonic growth, and normal development of the kidneys and testes. Deletion of only the\n                    <jats:italic>Crkl<\/jats:italic>\n                    gene in mice is sufficient to cause increased incidence of birth defects commonly seen in humans who possess deletion at 22q11.2. This study shows that\n                    <jats:italic>CRKL<\/jats:italic>\n                    is one of the key genes whose deletion contributes to the urogenital birth defects associated with multiple-gene deletion at chromosome 22q11.2, indicating a new target for gene therapy in affected patients.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1619523114","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T20:55:25Z","timestamp":1493067325000},"page":"4981-4986","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":48,"title":["Murine model indicates 22q11.2 signaling adaptor\n                    <i>CRKL<\/i>\n                    is a dosage-sensitive regulator of genitourinary development"],"prefix":"10.1073","volume":"114","author":[{"given":"Meade","family":"Haller","sequence":"first","affiliation":[{"name":"Department of Molecular &amp; Cellular Biology, Baylor College of Medicine, Houston, TX 77030;"},{"name":"Department of Urology, Baylor College of Medicine, Houston, TX 77030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianxing","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Medicine, Dan L. 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