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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,2,7]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Mesenchymal stem cells (MSCs) are thought to be derived from pericytes and exhibit a cellular, autonomous antimicrobial effector function that provides therapeutic potential against infectious diseases. However, the molecular mechanism remains unknown. Here, we demonstrate that human guanylate-binding protein 1 (hGBP1) is a key protective factor against\n                    <jats:italic>Toxoplasma gondii<\/jats:italic>\n                    infection in human MSCs (hMSCs). The recruitment of hGBP1 to the parasitophorous vacuole membrane in IFN-\u03b3\u2013stimulated hMSCs significantly inhibited\n                    <jats:italic>T. gondii<\/jats:italic>\n                    replication. Thus, our current study reveals an important function of hGBP1 in the defense against\n                    <jats:italic>T. gondii<\/jats:italic>\n                    and may shed new light on clarifying the mechanism of host defense properties of hMSCs.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1619665114","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T22:10:43Z","timestamp":1485382243000},"page":"1365-1370","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":58,"title":["Guanylate-binding protein 1 (GBP1) contributes to the immunity of human mesenchymal stromal cells against\n                    <i>Toxoplasma gondii<\/i>"],"prefix":"10.1073","volume":"114","author":[{"given":"Aiping","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;"},{"name":"Center for Stem Cell Biology and Tissue Engineering, The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4709-1507","authenticated-orcid":false,"given":"De-Hua","family":"Lai","sequence":"additional","affiliation":[{"name":"Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifa","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijun","family":"Huang","sequence":"additional","affiliation":[{"name":"Center for Stem Cell Biology and Tissue Engineering, The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China;"},{"name":"Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children\u2019s Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Ping","family":"Wu","sequence":"additional","affiliation":[{"name":"Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyong","family":"Chen","sequence":"additional","affiliation":[{"name":"Center for Stem Cell Biology and Tissue Engineering, The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China;"},{"name":"Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children\u2019s Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunxing","family":"Yan","sequence":"additional","affiliation":[{"name":"Center for Stem Cell Biology and Tissue Engineering, The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China;"},{"name":"Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children\u2019s Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Xia","sequence":"additional","affiliation":[{"name":"Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children\u2019s Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoff","family":"Hide","sequence":"additional","affiliation":[{"name":"Ecosystems and Environment Research Centre, School of Environment and Life Sciences, University of Salford, Salford M5 4WT, United Kingdom;"},{"name":"Biomedical Research Centre, School of Environment and Life Sciences, University of Salford, Salford M5 4WT, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao-Rong","family":"Lun","sequence":"additional","affiliation":[{"name":"Center for Parasitic Organisms, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China;"},{"name":"Ecosystems and Environment Research Centre, School of Environment and Life Sciences, University of Salford, Salford M5 4WT, United Kingdom;"},{"name":"Biomedical Research Centre, School of Environment and Life Sciences, University of Salford, Salford M5 4WT, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Ayala","sequence":"additional","affiliation":[{"name":"Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andy Peng","family":"Xiang","sequence":"additional","affiliation":[{"name":"Center for Stem Cell Biology and Tissue Engineering, The Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China;"},{"name":"Program of Stem Cells and Regenerative Medicine, Affiliated Guangzhou Women and Children\u2019s Hospital, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China;"},{"name":"Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, 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