{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T11:18:44Z","timestamp":1791371924432,"version":"4.3.1"},"reference-count":45,"publisher":"National Academy of Sciences","issue":"18","license":[{"start":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T00:00:00Z","timestamp":1506988800000},"content-version":"vor","delay-in-days":183,"URL":"http:\/\/www.pnas.org\/site\/misc\/userlicense.xhtml"}],"funder":[{"DOI":"10.13039\/501100000923","name":"Department of Industry, Innovation, Science, Research and Tertiary Education, Australian Government | Australian Research Council","doi-asserted-by":"publisher","award":["FT140101309"],"award-info":[{"award-number":["FT140101309"]}],"id":[{"id":"10.13039\/501100000923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,5,2]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The nature of overactive Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release in malignant hyperthermia (MH) and the mechanism of action of the drug dantrolene that arrests MH events are poorly understood. Here, we show that dantrolene stops overactive Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release by increasing the affinity of the ryanodine receptor (RyR) to Mg\n                    <jats:sup>2+<\/jats:sup>\n                    . In particular, Ca\n                    <jats:sup>2+<\/jats:sup>\n                    waves induced by MH triggers in human muscle are not affected by dantrolene unless Mg\n                    <jats:sup>2+<\/jats:sup>\n                    increases above resting levels, a condition met by the increase in MgATP hydrolysis during an MH episode. We suggest that only the combination of dantrolene and increased Mg\n                    <jats:sup>2+<\/jats:sup>\n                    can depress overactive Ca\n                    <jats:sup>2+<\/jats:sup>\n                    release and the resulting excessive heat production to arrest MH.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1619835114","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T20:43:34Z","timestamp":1491252214000},"page":"4811-4815","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":46,"title":["Dantrolene requires Mg\n                    <sup>2+<\/sup>\n                    to arrest malignant hyperthermia"],"prefix":"10.1073","volume":"114","author":[{"given":"Rocky H.","family":"Choi","sequence":"first","affiliation":[{"name":"School of Biomedical Sciences, The University of Queensland, Brisbane, QLD, 4072, 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