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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,5,9]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    <jats:sc>l<\/jats:sc>\n                    -galactofuranose (\n                    <jats:sc>l<\/jats:sc>\n                    -Gal\n                    <jats:italic>f<\/jats:italic>\n                    ), the furanose form of\n                    <jats:sc>l<\/jats:sc>\n                    -galactose, is rare in nature yet plays a central role in secondary metabolite structures with medicinal potential. Importantly, the biosynthetic enzymes and mechanisms driving\n                    <jats:sc>l<\/jats:sc>\n                    -Gal\n                    <jats:italic>f<\/jats:italic>\n                    biosynthesis have eluded characterization. We report here a previously unknown mutase, MtdL, that generates GDP-\n                    <jats:sc>l<\/jats:sc>\n                    -Gal\n                    <jats:italic>f<\/jats:italic>\n                    from its galactopyranose analog GDP-\n                    <jats:sc>l<\/jats:sc>\n                    -Gal\n                    <jats:italic>p<\/jats:italic>\n                    using unique chemistry. MtdL mediates the pyranose\u2013furanose conversion solely by the presence of bivalent cation. The ubiquitous nature of this Gal\n                    <jats:italic>p<\/jats:italic>\n                    \u2192 Gal\n                    <jats:italic>f<\/jats:italic>\n                    chemistry is suggested by numerous mutase homologs that are phylogenetically widespread in various phyla of Bacteria, Eukaryota, and Archaea. Thus, a genetic marker for\n                    <jats:sc>l<\/jats:sc>\n                    -Gal\n                    <jats:italic>f<\/jats:italic>\n                    -containing natural products and their producers has been discovered. Additionally, mutase homologs may constitute targets for antimicrobial drugs.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1620191114","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T20:55:25Z","timestamp":1493067325000},"page":"4948-4953","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":23,"title":["Deciphering the sugar biosynthetic pathway and tailoring steps of nucleoside antibiotic A201A unveils a GDP-\n                    <scp>l<\/scp>\n                    -galactose mutase"],"prefix":"10.1073","volume":"114","author":[{"given":"Qinghua","family":"Zhu","sequence":"first","affiliation":[{"name":"Chinese Academy of Sciences (CAS) Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Network for Applied Microbiology Center for Marine Microbiology, South China Sea Institute of Oceanology, CAS, Guangzhou 510301, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Chen","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences (CAS) Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Network for Applied Microbiology Center for Marine Microbiology, South China Sea Institute of Oceanology, CAS, Guangzhou 510301, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxiang","family":"Song","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences (CAS) Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Network for Applied Microbiology Center for Marine Microbiology, South China Sea Institute of Oceanology, CAS, Guangzhou 510301, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Huang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences (CAS) Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Network for Applied Microbiology Center for Marine Microbiology, South China Sea Institute of Oceanology, CAS, Guangzhou 510301, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Li","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences (CAS) Key Laboratory of Tropical Marine Bioresources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, Research Network for Applied Microbiology Center for Marine Microbiology, South China Sea Institute of Oceanology, CAS, Guangzhou 510301, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junying","family":"Ma","sequence":"additional","affiliation":[{"name":"Chinese 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