{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:09:37Z","timestamp":1790312977215,"version":"4.1.0"},"reference-count":74,"publisher":"National Academy of Sciences","issue":"18","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,5,2]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>To what extent is brain organization driven by innate genetic constraints, and how dependent is it on individual experience during early development? We show that an area of the visual system that processes both hands and tools can develop without sensorimotor experience in manipulating tools with one\u2019s hands. People born without hands show typical hand\u2013tool conjoined activity, in a region connected to the action network. Taken with findings from studies with people born blind, who also show intact hand and tool specialization in the visual system, these findings suggest that no specific sensory or motor experience is crucial for domain-specific organization of visual cortex. Instead, the results suggest that functional brain organization is largely innately determined.<\/jats:p>","DOI":"10.1073\/pnas.1620289114","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T20:50:22Z","timestamp":1492462222000},"page":"4787-4792","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":43,"title":["Sensorimotor-independent development of hands and tools selectivity in the visual cortex"],"prefix":"10.1073","volume":"114","author":[{"given":"Ella","family":"Striem-Amit","sequence":"first","affiliation":[{"name":"Department of Psychology, Harvard University, Cambridge, MA 02138;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Vannuscorps","sequence":"additional","affiliation":[{"name":"Department of Psychology, Harvard University, Cambridge, MA 02138;"},{"name":"Center for Mind\/Brain Sciences, University of Trento, 38068 Rovereto, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Caramazza","sequence":"additional","affiliation":[{"name":"Department of Psychology, Harvard University, Cambridge, MA 02138;"},{"name":"Center for Mind\/Brain Sciences, University of Trento, 38068 Rovereto, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,4,17]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1005062107"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1162\/089892998563752"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1080\/02643290600896449"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.60.110707.163532"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00924"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.psych.57.102904.190143"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.10.043"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4822-14.2015"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0983-13.2013"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0267-11.2011"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs364"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/33402"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3855"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2006.02.004"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2015.00002"},{"key":"e_1_3_3_16_2","first-page":"1229","article-title":"Experience shapes the development of neural substrates of face processing in human ventral temporal cortex","volume":"27","author":"Golarai G","year":"2017","unstructured":"G Golarai, A Liberman, K Grill-Spector, Experience shapes the development of neural substrates of face processing in human ventral temporal cortex. Cereb Cortex 27, 1229\u20131244 (2017).","journal-title":"Cereb Cortex"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1309963110"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.01.004"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2015.05.006"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2015.09.001"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12833"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00619.2011"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1322-13.2013"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhj086"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1038\/13217"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropsychologia.2009.07.008"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1093\/scan\/nsr018"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00876"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1177\/1535370214538740"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.01.025"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2016.02.002"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.1162\/jocn_a_00411"},{"key":"e_1_3_3_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2014.02.010"},{"key":"e_1_3_3_34_2","first-page":"1","article-title":"The large-scale organization of object-responsive cortex is reflected in resting-state network architecture","volume":"2016","author":"Konkle T","year":"2016","unstructured":"T Konkle, A Caramazza, The large-scale organization of object-responsive cortex is reflected in resting-state network architecture. Cereb Cortex 2016, 1\u201313 (2016).","journal-title":"Cereb Cortex"},{"key":"e_1_3_3_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.06.034"},{"key":"e_1_3_3_36_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4802-13.2014"},{"key":"e_1_3_3_37_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1412616111"},{"key":"e_1_3_3_38_2","doi-asserted-by":"publisher","DOI":"10.1076\/clin.12.4.482.7241"},{"key":"e_1_3_3_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.09.032"},{"key":"e_1_3_3_40_2","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2008.0008"},{"key":"e_1_3_3_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2009.11.063"},{"key":"e_1_3_3_42_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.50.5.1253"},{"key":"e_1_3_3_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2007.03.026"},{"key":"e_1_3_3_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhh169"},{"key":"e_1_3_3_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhn261"},{"key":"e_1_3_3_46_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0597-14.2014"},{"key":"e_1_3_3_47_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0500-14.2014"},{"key":"e_1_3_3_48_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3914-14.2015"},{"key":"e_1_3_3_49_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400707101"},{"key":"e_1_3_3_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2011.04.038"},{"key":"e_1_3_3_51_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.08.026"},{"key":"e_1_3_3_52_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.135"},{"key":"e_1_3_3_53_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1516978112"},{"key":"e_1_3_3_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2007.06.045"},{"key":"e_1_3_3_55_2","volume-title":"Co-planar Stereotaxic Atlas of the Human Brain","author":"Talairach J","year":"1988","unstructured":"J Talairach, P Tournoux Co-planar Stereotaxic Atlas of the Human Brain (Thieme, New York, 1988)."},{"key":"e_1_3_3_56_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.1999.0439"},{"key":"e_1_3_3_57_2","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.460010306"},{"key":"e_1_3_3_58_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330508"},{"key":"e_1_3_3_59_2","doi-asserted-by":"publisher","DOI":"10.1006\/nimg.2001.1037"},{"key":"e_1_3_3_60_2","doi-asserted-by":"publisher","DOI":"10.3758\/PBR.16.2.225"},{"key":"e_1_3_3_61_2","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340409"},{"key":"e_1_3_3_62_2","doi-asserted-by":"publisher","DOI":"10.1080\/02643290701290146"},{"key":"e_1_3_3_63_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0803733106"},{"key":"e_1_3_3_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.04.179"},{"key":"e_1_3_3_65_2","doi-asserted-by":"publisher","DOI":"10.1076\/jcen.25.4.521.13873"},{"key":"e_1_3_3_66_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0905267106"},{"key":"e_1_3_3_67_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2008.05.008"},{"key":"e_1_3_3_68_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2961"},{"key":"e_1_3_3_69_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2201"},{"key":"e_1_3_3_70_2","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2013.00493"},{"key":"e_1_3_3_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs010"},{"key":"e_1_3_3_72_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature05758"},{"key":"e_1_3_3_73_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1119125109"},{"key":"e_1_3_3_74_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0896-6273(03)00144-2"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1620289114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T02:26:32Z","timestamp":1649816792000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1620289114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,17]]},"references-count":74,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2017,5,2]]}},"alternative-id":["10.1073\/pnas.1620289114"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1620289114","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,17]]},"assertion":[{"value":"2017-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}