{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:55:09Z","timestamp":1791996909381,"version":"4.4.0"},"reference-count":32,"publisher":"National Academy of Sciences","issue":"18","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,5,2]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The Hippo pathway restricts cell proliferation and plays key roles in organ size control and tissue homeostasis. The crucial step of this pathway is the regulation of the transcriptional coactivators YAP\/TAZ by LATS1\/2 kinases. We report in the present study that deubiquitinase YOD1 acts as a positive regulator of YAP\/TAZ in controlling organ size. The significance of our study is the discovery of a regulatory mechanism for the Hippo pathway: high cell density miR-21\u2212YOD1\u2212ITCH\u2212LATS signaling cascade, which is parallel to a previously known high cell density MST1\/2\u2212LATS signaling cascade. Data from harnessing a mouse model that allowed inducible human YOD1 expression in mouse liver and liver cancer patients suggest mechanistic insights to expand our understanding about regulation of the Hippo pathway.<\/jats:p>","DOI":"10.1073\/pnas.1620306114","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T20:50:22Z","timestamp":1492462222000},"page":"4691-4696","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":68,"title":["Deubiquitinase YOD1 potentiates YAP\/TAZ activities through enhancing ITCH stability"],"prefix":"10.1073","volume":"114","author":[{"given":"Youngeun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Life Science, University of Seoul, Seoul 130-743, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wantae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Life Science, University of Seoul, Seoul 130-743, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghee","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Life Science, University of Seoul, Seoul 130-743, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Rae","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Mathematics, University of Seoul, Seoul 130-743, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyungjoo","family":"Cho","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyuk","family":"Moon","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Weonsang","family":"Ro","sequence":"additional","affiliation":[{"name":"Institute of Gastroenterology, Yonsei University College of Medicine, Seoul 120-752, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjeong","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeon-Mi","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Jae","family":"Myung","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Convergence Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul 138-736, Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eek-Hoon","family":"Jho","sequence":"additional","affiliation":[{"name":"Department of Life Science, University of Seoul, Seoul 130-743, Republic of Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,4,17]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.06.037"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1602907"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/nature10137"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1101273108"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3516"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2004.10.003"},{"key":"e_1_3_3_7_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605959200"},{"key":"e_1_3_3_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.430066"},{"key":"e_1_3_3_9_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.17.7748-7757.2004"},{"key":"e_1_3_3_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.09.016"},{"key":"e_1_3_3_11_2","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201540809"},{"key":"e_1_3_3_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1339"},{"key":"e_1_3_3_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.07.019"},{"key":"e_1_3_3_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/ncb3073"},{"key":"e_1_3_3_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.10.058"},{"key":"e_1_3_3_16_2","doi-asserted-by":"publisher","DOI":"10.4161\/cc.26672"},{"key":"e_1_3_3_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0811523106"},{"key":"e_1_3_3_18_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1004070"},{"key":"e_1_3_3_19_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00316.2011"},{"key":"e_1_3_3_20_2","doi-asserted-by":"publisher","DOI":"10.1242\/dev.031369"},{"key":"e_1_3_3_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng.722"},{"key":"e_1_3_3_22_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911427107"},{"key":"e_1_3_3_23_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0911409107"},{"key":"e_1_3_3_24_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.192856.112"},{"key":"e_1_3_3_25_2","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aac5418"},{"key":"e_1_3_3_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2010.02.035"},{"key":"e_1_3_3_27_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1103345108"},{"key":"e_1_3_3_28_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701773104"},{"key":"e_1_3_3_29_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M007300200"},{"key":"e_1_3_3_30_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0603449103"},{"key":"e_1_3_3_31_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-08-447409"},{"key":"e_1_3_3_32_2","doi-asserted-by":"publisher","DOI":"10.2144\/000113083"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1620306114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,13]],"date-time":"2022-04-13T02:26:26Z","timestamp":1649816786000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1620306114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,17]]},"references-count":32,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2017,5,2]]}},"alternative-id":["10.1073\/pnas.1620306114"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1620306114","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,17]]},"assertion":[{"value":"2017-04-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}