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Mambaquaretin-1 induces a purely aquaretic effect on mice and reduces cyst development in a mouse model. We produced mambaquaretin-1 by peptide synthesis and determined its X-ray structure, its binding mode, and functional properties. With high selectivity and without toxic metabolic byproducts associated with its peptidic nature, mambaquaretin-1 could become the preferential treatment for these disorders.<\/jats:p>","DOI":"10.1073\/pnas.1620454114","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T16:10:43Z","timestamp":1499098243000},"page":"7154-7159","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":56,"title":["Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease"],"prefix":"10.1073","volume":"114","author":[{"given":"Justyna","family":"Ciolek","sequence":"first","affiliation":[{"name":"Service d\u2019Ing\u00e9nierie Mol\u00e9culaire des Prot\u00e9ines, Institut des Sciences du Vivant Fr\u00e9d\u00e9ric Joliot, Commissariat \u00e0 l\u2019Energie Atomique, Universit\u00e9 Paris-Saclay, F-91191 Gif sur Yvette, 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