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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,2,7]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The carotid body (CB) is the major sensory organ responsible for monitoring arterial blood oxygen content. Glomus cells in the CB express heme oxygenase 2 (HO-2) and cystathionine-\u03b3-lyase (CSE), enzymes that generate the gasotransmitters carbon monoxide (CO) and hydrogen sulfide (H\n                    <jats:sub>2<\/jats:sub>\n                    S), respectively. In normoxia, CO inhibits CSE from producing H\n                    <jats:sub>2<\/jats:sub>\n                    S. During hypoxia, HO-2 produces less CO, resulting in increased H\n                    <jats:sub>2<\/jats:sub>\n                    S production, which stimulates CB activity, leading to increases in respiratory rate, heart rate, and blood pressure. We report that decreased CO and increased H\n                    <jats:sub>2<\/jats:sub>\n                    S generation in the CB causes sleep apnea in HO-2 knockout mice and spontaneously hypertensive rats. An inhibitor of CSE eliminates sleep apnea when administered to these animals, suggesting that this approach may have therapeutic utility in patients with sleep apnea.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1620717114","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T21:55:22Z","timestamp":1485208522000},"page":"1413-1418","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":79,"title":["Complementary roles of gasotransmitters CO and H\n                    <sub>2<\/sub>\n                    S in sleep apnea"],"prefix":"10.1073","volume":"114","author":[{"given":"Ying-Jie","family":"Peng","sequence":"first","affiliation":[{"name":"Institute of Integrative Physiology, Biological Sciences Division, University of Chicago, Chicago, IL 60637;"},{"name":"Center for Systems Biology of O2 Sensing, Department of Medicine, University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Integrative Physiology, Biological Sciences Division, University of Chicago, Chicago, IL 60637;"},{"name":"Center for Systems Biology of O2 Sensing, Department of Medicine, University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gridina","sequence":"additional","affiliation":[{"name":"Institute of Integrative Physiology, Biological Sciences Division, University of Chicago, Chicago, IL 60637;"},{"name":"Center for Systems Biology of O2 Sensing, Department of Medicine, University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Chupikova","sequence":"additional","affiliation":[{"name":"Institute of Integrative Physiology, Biological Sciences Division, University of Chicago, Chicago, IL 60637;"},{"name":"Center for Systems Biology of O2 Sensing, Department of Medicine, University of Chicago, Chicago, IL 60637;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"McCormick","sequence":"additional","affiliation":[{"name":"Life Sciences Group, Illinois Institute of Technology Research Institute, Chicago, IL 60616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Division of Pulmonary, Critical Care &amp; 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