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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,4,18]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    <jats:italic>Neisseria meningitidis<\/jats:italic>\n                    (Nm) remains a leading cause of meningitis and rapidly fatal sepsis in otherwise healthy individuals. Historically, Nm is not recognized as a significant cause of urogenital infections. Since 2015, a significant increase of meningococcal urethritis primarily among heterosexual men has been reported in multiple US cities. We defined that a unique nonencapsulated Nm clade, which belonged to the cc11\/ET-15 hyperinvasive lineage, was linked to these Nm urethritis clusters. The clade isolates causing urethritis clusters in the United States may have adapted to the urogenital environment with two unique molecular fingerprints: the insertion of IS1301 with associated deletion of capsule, enhancing mucosal adherence, and the acquisition of the gonococcal denitrification pathway by gene conversion, promoting anaerobic growth.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1620971114","type":"journal-article","created":{"date-parts":[[2017,4,3]],"date-time":"2017-04-03T20:43:34Z","timestamp":1491252214000},"page":"4237-4242","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":102,"title":["Emergence of a new\n                    <i>Neisseria meningitidis<\/i>\n                    clonal complex 11 lineage 11.2 clade as an effective urogenital pathogen"],"prefix":"10.1073","volume":"114","author":[{"given":"Yih-Ling","family":"Tzeng","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose A.","family":"Bazan","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Ohio State University College of Medicine, Columbus, OH 43210;"},{"name":"Sexual Health Clinic, Columbus Public Health, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail Norris","family":"Turner","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine, Ohio State University College of Medicine, Columbus, OH 43210;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Meningitis and Vaccine Preventable Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam C.","family":"Retchless","sequence":"additional","affiliation":[{"name":"Meningitis and Vaccine Preventable Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy D.","family":"Read","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelyn","family":"Toh","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Del Rio","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322;"},{"name":"Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA 30322;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David S.","family":"Stephens","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322;"},{"name":"Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA 30322"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,4,3]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-61779-346-2_1","article-title":"Neisseria meningitidis: Biology, microbiology, and epidemiology","volume":"799","author":"Rouphael NG","year":"2012","unstructured":"NG Rouphael, DS Stephens, Neisseria meningitidis: Biology, microbiology, and epidemiology. 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