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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,7,3]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Infertility is a global problem that afflicts 15% of couples, and in 50% of cases, the attributing factor is linked to men. Among these infertile men, 18% specifically exhibit decreased motility of sperm (asthenozoospermia). Sperm motility is dependent on the formation and functioning of the flagellum, a modified cilium used for locomotion. Cilia are present in almost every cell of vertebrates and are essential for proper organ functioning. Defects in cilia formation lead to severe syndromic diseases, termed ciliopathies, affecting numerous tissues (e.g., polycystic kidney disease), wherein male infertility is often comorbid. Advances in mouse genetics implicate several genes responsible for ciliopathies observed in humans. Here, we identify a nonsyndromic flagellum protein, TCTE1, that is required for sperm motility in mice.<\/jats:p>","DOI":"10.1073\/pnas.1621279114","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T16:10:43Z","timestamp":1499098243000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":102,"title":["TCTE1 is a conserved component of the dynein regulatory complex and is required for motility and metabolism in mouse spermatozoa"],"prefix":"10.1073","volume":"114","author":[{"given":"Julio M.","family":"Castaneda","sequence":"first","affiliation":[{"name":"Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030;"},{"name":"Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 5650871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Hua","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, People\u2019s Republic of China;"},{"name":"Department of Histology and Embryology, Nanjing Medical University, Nanjing 210029, People\u2019s Republic of China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Miyata","sequence":"additional","affiliation":[{"name":"Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 5650871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asami","family":"Oji","sequence":"additional","affiliation":[{"name":"Research Institute for Microbial Diseases, Osaka University, Suita, Osaka 5650871, Japan;"},{"name":"Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 5650871, Japan;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueshuai","family":"Guo","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Reproductive Medicine, Nanjing Medical University, 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J Cell Biol 92, 121\u2013131 (1982).","journal-title":"J Cell Biol"},{"key":"e_1_3_4_27_2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/S0959-440X(01)00266-4","article-title":"The leucine-rich repeat as a protein recognition motif","volume":"11","author":"Kobe B","year":"2001","unstructured":"B Kobe, AV Kajava, The leucine-rich repeat as a protein recognition motif. Curr Opin Struct Biol 11, 725\u2013732 (2001).","journal-title":"Curr Opin Struct Biol"},{"key":"e_1_3_4_28_2","doi-asserted-by":"crossref","first-page":"7704","DOI":"10.1073\/pnas.1608458113","article-title":"Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice","volume":"113","author":"Miyata H","year":"2016","unstructured":"H Miyata, , Genome engineering uncovers 54 evolutionarily conserved and testis-enriched genes that are not required for male fertility in mice. 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Dev Biol 237, 222\u2013231 (2001).","journal-title":"Dev Biol"},{"key":"e_1_3_4_39_2","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/s11248-012-9635-x","article-title":"Production of mouse pups from germline transmission-failed knockout chimeras","volume":"22","author":"Fujihara Y","year":"2013","unstructured":"Y Fujihara, K Kaseda, N Inoue, M Ikawa, M Okabe, Production of mouse pups from germline transmission-failed knockout chimeras. Transgenic Res 22, 195\u2013200 (2013).","journal-title":"Transgenic Res"},{"key":"e_1_3_4_40_2","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1074\/mcp.M500322-MCP200","article-title":"Proteomic profiling of accessory structures from the mouse sperm flagellum","volume":"5","author":"Cao W","year":"2006","unstructured":"W Cao, GL Gerton, SB Moss, Proteomic profiling of accessory structures from the mouse sperm flagellum. 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Genomics 85, 600\u2013607 (2005).","journal-title":"Genomics"},{"key":"e_1_3_4_43_2","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1002\/mrd.20485","article-title":"Molecular cloning and characterization of SRG-L, a novel mouse gene developmentally expressed in spermatogenic cells","volume":"73","author":"Ma Q","year":"2006","unstructured":"Q Ma, , Molecular cloning and characterization of SRG-L, a novel mouse gene developmentally expressed in spermatogenic cells. Mol Reprod Dev 73, 1075\u20131083 (2006).","journal-title":"Mol Reprod Dev"},{"key":"e_1_3_4_44_2","doi-asserted-by":"crossref","first-page":"5519","DOI":"10.1073\/pnas.90.12.5519","article-title":"A motility in the eukaryotic flagellum unrelated to flagellar beating","volume":"90","author":"Kozminski KG","year":"1993","unstructured":"KG Kozminski, KA Johnson, P Forscher, JL Rosenbaum, A motility in the eukaryotic flagellum unrelated to flagellar beating. Proc Natl Acad Sci USA 90, 5519\u20135523 (1993).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_45_2","doi-asserted-by":"crossref","first-page":"4358","DOI":"10.1091\/mbc.E15-08-0578","article-title":"Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm","volume":"26","author":"San Agustin JT","year":"2015","unstructured":"JT San Agustin, GJ Pazour, GB Witman, Intraflagellar transport is essential for mammalian spermiogenesis but is absent in mature sperm. Mol Biol Cell 26, 4358\u20134372 (2015).","journal-title":"Mol Biol Cell"},{"key":"e_1_3_4_46_2","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ncb735","article-title":"Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel mpartner Hippi","volume":"4","author":"Gervais FG","year":"2002","unstructured":"FG Gervais, , Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel mpartner Hippi. Nat Cell Biol 4, 95\u2013105 (2002).","journal-title":"Nat Cell Biol"},{"key":"e_1_3_4_47_2","doi-asserted-by":"crossref","first-page":"W741","DOI":"10.1093\/nar\/gki475","article-title":"WebGestalt: An integrated system for exploring gene sets in various biological contexts","volume":"33","author":"Zhang B","year":"2005","unstructured":"B Zhang, S Kirov, J Snoddy, WebGestalt: An integrated system for exploring gene sets in various biological contexts. Nucleic Acids Res 33, W741\u2013748 (2005).","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_4_48_2","doi-asserted-by":"crossref","first-page":"W77","DOI":"10.1093\/nar\/gkt439","article-title":"WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): Update 2013","volume":"41","author":"Wang J","year":"2013","unstructured":"J Wang, D Duncan, Z Shi, B Zhang, WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): Update 2013. Nucleic Acids Res 41, W77\u201383 (2013).","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_4_49_2","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1095\/biolreprod.109.080580","article-title":"Molecular complex of three testis-specific isozymes associated with the mouse sperm fibrous sheath: Hexokinase 1, phosphofructokinase M, and glutathione S-transferase mu class 5","volume":"82","author":"Nakamura N","year":"2010","unstructured":"N Nakamura, C Mori, EM Eddy, Molecular complex of three testis-specific isozymes associated with the mouse sperm fibrous sheath: Hexokinase 1, phosphofructokinase M, and glutathione S-transferase mu class 5. Biol Reprod 82, 504\u2013515 (2010).","journal-title":"Biol Reprod"},{"key":"e_1_3_4_50_2","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/mrd.22217","article-title":"Male mice express spermatogenic cell-specific triosephosphate isomerase isozymes","volume":"80","author":"Ijiri TW","year":"2013","unstructured":"TW Ijiri, , Male mice express spermatogenic cell-specific triosephosphate isomerase isozymes. Mol Reprod Dev 80, 862\u2013870 (2013).","journal-title":"Mol Reprod Dev"},{"key":"e_1_3_4_51_2","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1095\/biolreprod.103.026054","article-title":"Glycolysis plays a major role for adenosine triphosphate supplementation in mouse sperm flagellar movement","volume":"71","author":"Mukai C","year":"2004","unstructured":"C Mukai, M Okuno, Glycolysis plays a major role for adenosine triphosphate supplementation in mouse sperm flagellar movement. Biol Reprod 71, 540\u2013547 (2004).","journal-title":"Biol Reprod"},{"key":"e_1_3_4_52_2","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/326501a0","article-title":"Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene","volume":"326","author":"McCarrey JR","year":"1987","unstructured":"JR McCarrey, K Thomas, Human testis-specific PGK gene lacks introns and possesses characteristics of a processed gene. Nature 326, 501\u2013505 (1987).","journal-title":"Nature"},{"key":"e_1_3_4_53_2","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S0015-0282(16)41543-8","article-title":"Energy metabolism of spermatozoa. V. The Embden-Myerhof pathway of glycolysis: Activities of pathway enzymes in hypotonically treated rabbit epididymal spermatozoa","volume":"26","author":"Storey BT","year":"1975","unstructured":"BT Storey, FJ Kayne, Energy metabolism of spermatozoa. V. The Embden-Myerhof pathway of glycolysis: Activities of pathway enzymes in hypotonically treated rabbit epididymal spermatozoa. Fertil Steril 26, 1257\u20131265 (1975).","journal-title":"Fertil Steril"},{"key":"e_1_3_4_54_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1095\/biolreprod49.2.191","article-title":"Unique hexokinase messenger ribonucleic acids lacking the porin-binding domain are developmentally expressed in mouse spermatogenic cells","volume":"49","author":"Mori C","year":"1993","unstructured":"C Mori, JE Welch, KD Fulcher, DA O\u2019Brien, EM Eddy, Unique hexokinase messenger ribonucleic acids lacking the porin-binding domain are developmentally expressed in mouse spermatogenic cells. Biol Reprod 49, 191\u2013203 (1993).","journal-title":"Biol Reprod"},{"key":"e_1_3_4_55_2","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1042\/bj2420619","article-title":"Molecular cloning and nucleotide sequence of the cDNA for sperm-specific lactate dehydrogenase-C from mouse","volume":"242","author":"Sakai I","year":"1987","unstructured":"I Sakai, FS Sharief, SS Li, Molecular cloning and nucleotide sequence of the cDNA for sperm-specific lactate dehydrogenase-C from mouse. Biochem J 242, 619\u2013622 (1987).","journal-title":"Biochem J"},{"key":"e_1_3_4_56_2","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1095\/biolreprod46.5.869","article-title":"Expression of a glyceraldehyde 3-phosphate dehydrogenase gene specific to mouse spermatogenic cells","volume":"46","author":"Welch JE","year":"1992","unstructured":"JE Welch, EC Schatte, DA O\u2019Brien, EM Eddy, Expression of a glyceraldehyde 3-phosphate dehydrogenase gene specific to mouse spermatogenic cells. Biol Reprod 46, 869\u2013878 (1992).","journal-title":"Biol Reprod"},{"key":"e_1_3_4_57_2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1095\/biolreprod.105.049684","article-title":"Multiple glycolytic enzymes are tightly bound to the fibrous sheath of mouse spermatozoa","volume":"75","author":"Krisfalusi M","year":"2006","unstructured":"M Krisfalusi, K Miki, PL Magyar, DA O\u2019Brien, Multiple glycolytic enzymes are tightly bound to the fibrous sheath of mouse spermatozoa. Biol Reprod 75, 270\u2013278 (2006).","journal-title":"Biol Reprod"},{"key":"e_1_3_4_58_2","doi-asserted-by":"crossref","first-page":"F37","DOI":"10.1083\/jcb.151.5.F37","article-title":"The 9 + 2 axoneme anchors multiple inner arm dyneins and a network of kinases and phosphatases that control motility","volume":"151","author":"Porter ME","year":"2000","unstructured":"ME Porter, WS Sale, The 9 + 2 axoneme anchors multiple inner arm dyneins and a network of kinases and phosphatases that control motility. J Cell Biol 151, F37\u2013F42 (2000).","journal-title":"J Cell Biol"},{"key":"e_1_3_4_59_2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.devcel.2004.12.005","article-title":"Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa","volume":"8","author":"Ihara M","year":"2005","unstructured":"M Ihara, , Cortical organization by the septin cytoskeleton is essential for structural and mechanical integrity of mammalian spermatozoa. Dev Cell 8, 343\u2013352 (2005).","journal-title":"Dev Cell"},{"key":"e_1_3_4_60_2","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1093\/humrep\/dep020","article-title":"Absence of annulus in human asthenozoospermia: Case report","volume":"24","author":"Lhuillier P","year":"2009","unstructured":"P Lhuillier, , Absence of annulus in human asthenozoospermia: Case report. Hum Reprod 24, 1296\u20131303 (2009).","journal-title":"Hum Reprod"},{"key":"e_1_3_4_61_2","doi-asserted-by":"crossref","first-page":"31666","DOI":"10.1038\/srep31666","article-title":"CRISPR\/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in mice","volume":"6","author":"Oji A","year":"2016","unstructured":"A Oji, , CRISPR\/Cas9 mediated genome editing in ES cells and its application for chimeric analysis in mice. Sci Rep 6, 31666 (2016).","journal-title":"Sci Rep"},{"key":"e_1_3_4_62_2","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/cr.2013.46","article-title":"Generation of gene-modified mice via Cas9\/RNA-mediated gene targeting","volume":"23","author":"Shen B","year":"2013","unstructured":"B Shen, , Generation of gene-modified mice via Cas9\/RNA-mediated gene targeting. Cell Res 23, 720\u2013723 (2013).","journal-title":"Cell Res"},{"key":"e_1_3_4_63_2","doi-asserted-by":"crossref","first-page":"7054","DOI":"10.1073\/pnas.1324025111","article-title":"Lack of testicular seipin causes teratozoospermia syndrome in men","volume":"111","author":"Jiang M","year":"2014","unstructured":"M Jiang, , Lack of testicular seipin causes teratozoospermia syndrome in men. Proc Natl Acad Sci USA 111, 7054\u20137059 (2014).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_64_2","doi-asserted-by":"crossref","first-page":"19039","DOI":"10.1074\/jbc.M708590200","article-title":"Meichroacidin containing the membrane occupation and recognition nexus motif is essential for spermatozoa morphogenesis","volume":"283","author":"Tokuhiro K","year":"2008","unstructured":"K Tokuhiro, , Meichroacidin containing the membrane occupation and recognition nexus motif is essential for spermatozoa morphogenesis. J Biol Chem 283, 19039\u201319048 (2008).","journal-title":"J Biol Chem"},{"key":"e_1_3_4_65_2","doi-asserted-by":"crossref","first-page":"3583","DOI":"10.1242\/dev.081778","article-title":"SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia","volume":"139","author":"Fujihara Y","year":"2012","unstructured":"Y Fujihara, , SPACA1-deficient male mice are infertile with abnormally shaped sperm heads reminiscent of globozoospermia. Development 139, 3583\u20133589 (2012).","journal-title":"Development"},{"key":"e_1_3_4_66_2","doi-asserted-by":"crossref","first-page":"5639","DOI":"10.1074\/jbc.M110.140152","article-title":"Calsperin is a testis-specific chaperone required for sperm fertility","volume":"286","author":"Ikawa M","year":"2011","unstructured":"M Ikawa, , Calsperin is a testis-specific chaperone required for sperm fertility. J Biol Chem 286, 5639\u20135646 (2011).","journal-title":"J Biol Chem"},{"key":"e_1_3_4_67_2","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.15252\/embj.201386855","article-title":"Reduced pachytene piRNAs and translation underlie spermiogenic arrest in Maelstrom mutant mice","volume":"33","author":"Casta\u00f1eda J","year":"2014","unstructured":"J Casta\u00f1eda, , Reduced pachytene piRNAs and translation underlie spermiogenic arrest in Maelstrom mutant mice. EMBO J 33, 1999\u20132019 (2014).","journal-title":"EMBO J"},{"key":"e_1_3_4_68_2","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/mrd.22358","article-title":"The acrosomal protein SP-10 (Acrv1) is an ideal marker for staging of the cycle of seminiferous epithelium in the mouse","volume":"81","author":"Osuru HP","year":"2014","unstructured":"HP Osuru, , The acrosomal protein SP-10 (Acrv1) is an ideal marker for staging of the cycle of seminiferous epithelium in the mouse. Mol Reprod Dev 81, 896\u2013907 (2014).","journal-title":"Mol Reprod Dev"},{"key":"e_1_3_4_69_2","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1038\/nprot.2008.150","article-title":"The SCX\/IMAC enrichment approach for global phosphorylation analysis by mass spectrometry","volume":"3","author":"Vill\u00e9n J","year":"2008","unstructured":"J Vill\u00e9n, SP Gygi, The SCX\/IMAC enrichment approach for global phosphorylation analysis by mass spectrometry. Nat Protoc 3, 1630\u20131638 (2008).","journal-title":"Nat Protoc"},{"key":"e_1_3_4_70_2","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jprot.2013.02.008","article-title":"Comparative evaluation of electrostatic repulsion-hydrophilic interaction chromatography (ERLIC) and high-pH reversed phase (Hp-RP) chromatography in profiling of rat kidney proteome","volume":"82","author":"Hao P","year":"2013","unstructured":"P Hao, Y Ren, B Dutta, SK Sze, Comparative evaluation of electrostatic repulsion-hydrophilic interaction chromatography (ERLIC) and high-pH reversed phase (Hp-RP) chromatography in profiling of rat kidney proteome. J Proteomics 82, 254\u2013262 (2013).","journal-title":"J Proteomics"},{"key":"e_1_3_4_71_2","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox J","year":"2008","unstructured":"J Cox, M Mann, MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification. Nat Biotechnol 26, 1367\u20131372 (2008).","journal-title":"Nat Biotechnol"},{"key":"e_1_3_4_72_2","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1002\/pmic.200900375","article-title":"A guided tour of the Trans-Proteomic Pipeline","volume":"10","author":"Deutsch EW","year":"2010","unstructured":"EW Deutsch, , A guided tour of the Trans-Proteomic Pipeline. Proteomics 10, 1150\u20131159 (2010).","journal-title":"Proteomics"},{"key":"e_1_3_4_73_2","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","article-title":"2016 update of the PRIDE database and its related tools","volume":"44","author":"Vizca\u00edno JA","year":"2016","unstructured":"JA Vizca\u00edno, , 2016 update of the PRIDE database and its related tools. Nucleic Acids Res 44, D447\u2013D456 (2016).","journal-title":"Nucleic Acids Res"},{"key":"e_1_3_4_74_2","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1002\/pmic.201200489","article-title":"Scanning of novel cancer\/testis proteins by human testis proteomic analysis","volume":"13","author":"Liu M","year":"2013","unstructured":"M Liu, , Scanning of novel cancer\/testis proteins by human testis proteomic analysis. 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