{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T00:40:06Z","timestamp":1791160806266,"version":"4.1.0"},"reference-count":43,"publisher":"National Academy of Sciences","issue":"16","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2002,8,6]]},"abstract":"<jats:p>\n                    Carotenoids are currently being intensely investigated regarding their potential to lower the risk of chronic disease and vitamin A deficiency. Invertebrate models in which vitamin A deficiency is not lethal allow the isolation of blind but viable mutants affected in the pathway leading from dietary carotenoids to vitamin A. Using a mutant in one of these model systems,\n                    <jats:italic>Drosophila<\/jats:italic>\n                    , the vitamin A-forming enzyme has recently been molecularly identified. We now show that the molecular basis for the blindness of a different\n                    <jats:italic>Drosophila<\/jats:italic>\n                    mutant,\n                    <jats:italic>ninaD<\/jats:italic>\n                    , is a defect in the cellular uptake of carotenoids. The\n                    <jats:italic>ninaD<\/jats:italic>\n                    gene encodes a class B scavenger receptor essential for the formation of the visual chromophore. A loss of this function results in a carotenoid-free and thus vitamin A-deficient phenotype. Our investigations provide molecular insight into how carotenoids may be distributed into cells of target tissues in animals and indicate a crucial role of class B scavenger receptors rendering dietary carotenoids available for subsequent cell metabolism, as needed for their various physiological functions.\n                  <\/jats:p>","DOI":"10.1073\/pnas.162182899","type":"journal-article","created":{"date-parts":[[2002,9,30]],"date-time":"2002-09-30T12:42:53Z","timestamp":1033389773000},"page":"10581-10586","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":235,"title":["A class B scavenger receptor mediates the cellular uptake of carotenoids in\n                    <i>Drosophila<\/i>"],"prefix":"10.1073","volume":"99","author":[{"given":"Cornelia","family":"Kiefer","sequence":"first","affiliation":[{"name":"Institute of Biology I, Neurobiology, and Animal Physiology, Albert-Ludwig University of Freiburg, Hauptstrasse 1, D-79104 Freiburg, Germany; and Department of Biology, New York University, New York, NY 10003-6688"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerich","family":"Sumser","sequence":"additional","affiliation":[{"name":"Institute of Biology I, Neurobiology, and Animal Physiology, Albert-Ludwig University of Freiburg, Hauptstrasse 1, D-79104 Freiburg, Germany; and Department of Biology, New York University, New York, NY 10003-6688"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias F.","family":"Wernet","sequence":"additional","affiliation":[{"name":"Institute of Biology I, Neurobiology, and Animal Physiology, Albert-Ludwig University of Freiburg, Hauptstrasse 1, D-79104 Freiburg, Germany; and Department of Biology, New York University, New York, NY 10003-6688"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"von Lintig","sequence":"additional","affiliation":[{"name":"Institute of Biology I, Neurobiology, and Animal Physiology, Albert-Ludwig University of Freiburg, Hauptstrasse 1, D-79104 Freiburg, Germany; and Department of Biology, New York University, New York, NY 10003-6688"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2002,7,22]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.9.15.8529834"},{"key":"e_1_3_3_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0899-9007(01)00640-2"},{"key":"e_1_3_3_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.2.557"},{"key":"e_1_3_3_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.2.571"},{"key":"e_1_3_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90200-7"},{"key":"e_1_3_3_6_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.10.5.8621054"},{"key":"e_1_3_3_7_2","first-page":"477","volume":"36","author":"Stephenson R. 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