{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:49:11Z","timestamp":1790646551909,"version":"4.1.0"},"reference-count":60,"publisher":"National Academy of Sciences","issue":"39","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,9,26]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    The\n                    <jats:italic>ANK3<\/jats:italic>\n                    gene locus has been repeatedly shown to confer risk for bipolar disorder in genome-wide association studies. We generated a mouse model with conditional disruption of\n                    <jats:italic>ANK3<\/jats:italic>\n                    gene in neurons in adult forebrain (Ank-G cKO). The mice showed robust behavioral phenotypes reminiscent of aspects of human mania, ameliorated by antimania drugs. Repeated stress resulted in dramatic behavioral changes between \u201cmania-like\u201d and \u201cdepression-like\u201d status, reminiscent of human bipolar disorder. Histological studies imply that cortical microcircuitry alterations are involved in pathogenesis. Overall, we suggest that this Ank-G cKO mouse model recapitulates core features of human bipolar disorder, and may be useful for studying disease pathophysiology and for developing experimental therapeutics.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1700689114","type":"journal-article","created":{"date-parts":[[2017,9,11]],"date-time":"2017-09-11T21:00:49Z","timestamp":1505163649000},"page":"10479-10484","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":72,"title":["Genetic disruption of ankyrin-G in adult mouse forebrain causes cortical synapse alteration and behavior reminiscent of bipolar disorder"],"prefix":"10.1073","volume":"114","author":[{"given":"Shanshan","family":"Zhu","sequence":"first","affiliation":[{"name":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine (JHU SOM), Baltimore, MD 21287;"},{"name":"Department of Psychiatry, JHU SOM, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6000-567X","authenticated-orcid":false,"given":"Zachary A.","family":"Cordner","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, JHU SOM, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiali","family":"Xiong","sequence":"additional","affiliation":[{"name":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine (JHU SOM), Baltimore, MD 21287;"},{"name":"Department of Psychiatry, JHU SOM, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Tso","family":"Chiu","sequence":"additional","affiliation":[{"name":"Section on Molecular Neurobiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arabiye","family":"Artola","sequence":"additional","affiliation":[{"name":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine (JHU SOM), Baltimore, MD 21287;"},{"name":"Department of Psychiatry, JHU SOM, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanning","family":"Zuo","sequence":"additional","affiliation":[{"name":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine (JHU SOM), Baltimore, MD 21287;"},{"name":"Department of Psychiatry, JHU SOM, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Nelson","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, University of Michigan Medical School, Ann Arbor, MI 48109;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Yeon","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine (JHU SOM), Baltimore, MD 21287;"},{"name":"Department of Psychiatry, JHU SOM, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalya","family":"Zaika","sequence":"additional","affiliation":[{"name":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine (JHU SOM), Baltimore, MD 21287;"},{"name":"Department of Psychiatry, JHU SOM, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian M.","family":"Woolums","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Molecular Sciences, JHU SOM, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evan J.","family":"Hess","sequence":"additional","affiliation":[{"name":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine (JHU SOM), Baltimore, MD 21287;"},{"name":"Department of Psychiatry, JHU SOM, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine (JHU SOM), Baltimore, MD 21287;"},{"name":"Department of Psychiatry, JHU SOM, Baltimore, MD 21287;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"De-Maw","family":"Chuang","sequence":"additional","affiliation":[{"name":"Section on Molecular Neurobiology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail M.","family":"Pletnikov","sequence":"additional","affiliation":[{"name":"Division of Neurobiology, Department of Psychiatry, Johns Hopkins University School of Medicine (JHU SOM), Baltimore, MD 21287;"},{"name":"Department of Psychiatry, JHU SOM, Baltimore, MD 21287;"},{"name":"The Solomon H. 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