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We propose that Hcrt is critical for spontaneous waking but that enforced waking relies on other neuromodulators, such as norepinephrine.<\/jats:p>","DOI":"10.1073\/pnas.1700983114","type":"journal-article","created":{"date-parts":[[2017,7,3]],"date-time":"2017-07-03T16:10:43Z","timestamp":1499098243000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":126,"title":["Hypocretin (orexin) is critical in sustaining theta\/gamma-rich waking behaviors that drive sleep need"],"prefix":"10.1073","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5314-5620","authenticated-orcid":false,"given":"Anne","family":"Vassalli","sequence":"first","affiliation":[{"name":"Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland;"},{"name":"Department of Physiology, University of Lausanne, CH-1005 Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2500-2921","authenticated-orcid":false,"given":"Paul","family":"Franken","sequence":"additional","affiliation":[{"name":"Center for Integrative Genomics, University of Lausanne, CH-1015 Lausanne, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,6,19]]},"reference":[{"key":"e_1_3_3_1_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.09.012"},{"key":"e_1_3_3_2_2","first-page":"R161","article-title":"Timing of human sleep: Recovery process gated by a circadian pacemaker","volume":"246","author":"Daan S","year":"1984","unstructured":"S Daan, DG Beersma, AA Borb\u00e9ly, Timing of human sleep: Recovery process gated by a circadian pacemaker. 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