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Both Tln isoforms can independently support costamere, CM, and whole-heart function. Yet, combined deletion of CM Tln1 and Tln2 destabilized the myocardium, leading to heart failure. This study significantly advances knowledge about the basic biology of talin, particularly given its study in vivo, and advances understanding of Tln\u2019s role in maintenance of normal heart muscle function.<\/jats:p>","DOI":"10.1073\/pnas.1701416114","type":"journal-article","created":{"date-parts":[[2017,7,11]],"date-time":"2017-07-11T21:10:19Z","timestamp":1499807419000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":68,"title":["Loss of mouse cardiomyocyte talin-1 and talin-2 leads to \u03b2-1 integrin reduction, costameric instability, and dilated cardiomyopathy"],"prefix":"10.1073","volume":"114","author":[{"given":"Ana Maria","family":"Manso","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, University of California at San Diego School of Medicine, La Jolla, CA 92093;"},{"name":"Cardiology Section, Department of Medicine, Veterans Administration Healthcare, San Diego, CA 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