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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,8,8]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Endogenization of retroviruses has occurred multiple times in the course of vertebrate evolution, with the captured retroviral envelope syncytins playing a role in placentation in mammals, including marsupials. Here, we identify an endogenous retroviral envelope protein with unprecedented properties, including a specific cleavage process resulting in the shedding of its extracellular moiety in the human blood circulation. This protein is conserved in all simians\u2014with a homologous protein found in marsupials\u2014with a \u201cstemness\u201d expression in embryonic and reprogrammed stem cells, as well as in the placenta and some human tumors, especially ovarian tumors. This protein could constitute a versatile marker\u2014and possibly an effector\u2014of specific cellular states and being shed, be immunodetected in the blood.<\/jats:p>","DOI":"10.1073\/pnas.1702204114","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T12:40:55Z","timestamp":1502196055000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":86,"title":["HEMO, an ancestral endogenous retroviral envelope protein shed in the blood of pregnant women and expressed in pluripotent stem cells and tumors"],"prefix":"10.1073","volume":"114","author":[{"given":"Odile","family":"Heidmann","sequence":"first","affiliation":[{"name":"Unit\u00e9 Physiologie et Pathologie Mol\u00e9culaires des R\u00e9trovirus Endog\u00e8nes et Infectieux, CNRS UMR 9196, Gustave Roussy, Villejuif, F-94805, France;"},{"name":"UMR9196, Universit\u00e9 Paris-Sud, Orsay, F-91405, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"B\u00e9guin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Physiologie et Pathologie Mol\u00e9culaires des R\u00e9trovirus Endog\u00e8nes et Infectieux, CNRS UMR 9196, Gustave Roussy, Villejuif, F-94805, France;"},{"name":"UMR9196, Universit\u00e9 Paris-Sud, Orsay, F-91405, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janio","family":"Paternina","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Physiologie et Pathologie Mol\u00e9culaires des R\u00e9trovirus Endog\u00e8nes et Infectieux, CNRS UMR 9196, Gustave Roussy, Villejuif, F-94805, France;"},{"name":"UMR9196, Universit\u00e9 Paris-Sud, Orsay, F-91405, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rapha\u00ebl","family":"Berthier","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Physiologie et Pathologie Mol\u00e9culaires des R\u00e9trovirus Endog\u00e8nes et Infectieux, CNRS UMR 9196, Gustave Roussy, Villejuif, F-94805, France;"},{"name":"UMR9196, Universit\u00e9 Paris-Sud, Orsay, F-91405, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Deloger","sequence":"additional","affiliation":[{"name":"Plateforme de Bioinformatique, INSERM US23\/CNRS UMS3655, Gustave Roussy, Villejuif, F-94805, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Bawa","sequence":"additional","affiliation":[{"name":"Plateforme d'\u00c9valuation Pr\u00e9clinique, Laboratoire de Pathologie Exp\u00e9rimentale, Gustave Roussy, Villejuif, F-94805, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Heidmann","sequence":"additional","affiliation":[{"name":"Unit\u00e9 Physiologie et Pathologie Mol\u00e9culaires des R\u00e9trovirus Endog\u00e8nes et Infectieux, CNRS UMR 9196, Gustave Roussy, Villejuif, F-94805, France;"},{"name":"UMR9196, Universit\u00e9 Paris-Sud, Orsay, F-91405, France;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,7,24]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrg3199","article-title":"Endogenous viruses: Insights into viral evolution and impact on host biology","volume":"13","author":"Feschotte C","year":"2012","unstructured":"C Feschotte, C Gilbert, Endogenous viruses: Insights into viral evolution and impact on host biology. 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