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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,4,4]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    A pathogenetic role of\n                    <jats:italic>NOTCH1<\/jats:italic>\n                    in chronic lymphocytic leukemia (CLL) has been implied by the presence of deregulating mutations in a relatively small fraction of cases. Our results now indicate that \u223c50% of CLL cases devoid of mutations express the active form of NOTCH1 ICN1 (intracellular portion of NOTCH1), thus implicating a much broader role of this transcription factor in the disease. ICN1\n                    <jats:sup>+<\/jats:sup>\n                    CLL cases display equivalent NOTCH1-dependent transcriptional responses regardless of the gene mutation status, indicating that the detection of ICN1 represents a reliable biomarker of\n                    <jats:italic>NOTCH1<\/jats:italic>\n                    activation for diagnostic and therapeutic targeting. Finally, our results identify the NOTCH1-dependent transcriptional program in CLL cells, thus providing direct insights into the pathogenesis of a large fraction of CLL cases.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1702564114","type":"journal-article","created":{"date-parts":[[2017,3,17]],"date-time":"2017-03-17T22:58:36Z","timestamp":1489791516000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":121,"title":["Common nonmutational\n                    <i>NOTCH1<\/i>\n                    activation in chronic lymphocytic leukemia"],"prefix":"10.1073","volume":"114","author":[{"given":"Giulia","family":"Fabbri","sequence":"first","affiliation":[{"name":"Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antony B.","family":"Holmes","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Viganotti","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio","family":"Scuoppo","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Belver","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Herranz","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Jie","family":"Yan","sequence":"additional","affiliation":[{"name":"The Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, NY 11030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasmine","family":"Kieso","sequence":"additional","affiliation":[{"name":"The Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, NY 11030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Rossi","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology Institute of Southern Switzerland, 6500 Bellinzona, Switzerland;"},{"name":"Lymphoma and Genomics Research Program, Institute of Oncology Research, 6500 Bellinzona, Switzerland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Gaidano","sequence":"additional","affiliation":[{"name":"Division of Haematology, Department of Translational Medicine, Universit\u00e0 del Piemonte Orientale, 28100 Novara, Italy;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Chiorazzi","sequence":"additional","affiliation":[{"name":"The Feinstein Institute for Medical Research, Northwell Health, Manhasset, New York, NY 11030;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo A.","family":"Ferrando","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032;"},{"name":"Department of Pathology and Cell Biology, Columbia University, New York, NY 10032;"},{"name":"Department of Pediatrics, Columbia University, New York, NY 10032;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Dalla-Favera","sequence":"additional","affiliation":[{"name":"Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032;"},{"name":"Department of Pathology and Cell Biology, Columbia University, New York, NY 10032;"},{"name":"Department of Genetics &amp; Development, Columbia University, New York, NY 10032;"},{"name":"Department of Microbiology &amp; Immunology, Columbia University, New York, NY 10032"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,3,17]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nrc.2016.8","article-title":"The molecular pathogenesis of chronic lymphocytic leukaemia","volume":"16","author":"Fabbri G","year":"2016","unstructured":"G Fabbri, R Dalla-Favera, The molecular pathogenesis of chronic lymphocytic leukaemia. 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Blood 114, 4832\u20134842 (2009).","journal-title":"Blood"},{"key":"e_1_3_4_49_2","doi-asserted-by":"crossref","first-page":"3391","DOI":"10.1182\/blood-2010-09-302174","article-title":"The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation","volume":"117","author":"Rossi D","year":"2011","unstructured":"D Rossi, , The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation. Blood 117, 3391\u20133401 (2011).","journal-title":"Blood"},{"key":"e_1_3_4_50_2","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1038\/nm.3665","article-title":"A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia","volume":"20","author":"Herranz D","year":"2014","unstructured":"D Herranz, , A NOTCH1-driven MYC enhancer promotes T cell development, transformation and acute lymphoblastic leukemia. 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Cancer Discov 5, 1058\u20131071 (2015).","journal-title":"Cancer Discov"},{"key":"e_1_3_4_53_2","doi-asserted-by":"crossref","first-page":"4783","DOI":"10.1182\/blood-2012-04-423517","article-title":"High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations","volume":"120","author":"Edelmann J","year":"2012","unstructured":"J Edelmann, , High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations. Blood 120, 4783\u20134794 (2012).","journal-title":"Blood"},{"key":"e_1_3_4_54_2","doi-asserted-by":"crossref","first-page":"pdb.prot5156","DOI":"10.1101\/pdb.prot5156","article-title":"The OP9-DL1 system: Generation of T-lymphocytes from embryonic or hematopoietic stem cells in vitro","volume":"2009","author":"Holmes R","year":"2009","unstructured":"R Holmes, JC Zuniga-Pflucker, The OP9-DL1 system: Generation of T-lymphocytes from embryonic or hematopoietic stem cells in vitro. Cold Spring Harb Protoc 2009, pdb.prot5156 (2009).","journal-title":"Cold Spring Harb Protoc"},{"key":"e_1_3_4_55_2","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1084\/jem.20070876","article-title":"FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors","volume":"204","author":"O\u2019Neil J","year":"2007","unstructured":"J O\u2019Neil, , FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med 204, 1813\u20131824 (2007).","journal-title":"J Exp Med"},{"key":"e_1_3_4_56_2","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1172\/JCI23409","article-title":"In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells","volume":"115","author":"Messmer BT","year":"2005","unstructured":"BT Messmer, , In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells. J Clin Invest 115, 755\u2013764 (2005).","journal-title":"J Clin Invest"},{"key":"e_1_3_4_57_2","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.immuni.2010.11.008","article-title":"Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis","volume":"33","author":"G\u00f3mez-del Arco P","year":"2010","unstructured":"P G\u00f3mez-del Arco, , Alternative promoter usage at the Notch1 locus supports ligand-independent signaling in T cell development and leukemogenesis. Immunity 33, 685\u2013698 (2010).","journal-title":"Immunity"},{"key":"e_1_3_4_58_2","doi-asserted-by":"crossref","first-page":"5455","DOI":"10.1182\/blood-2010-05-286328","article-title":"Deletion-based mechanisms of Notch1 activation in T-ALL: Key roles for RAG recombinase and a conserved internal translational start site in Notch1","volume":"116","author":"Ashworth TD","year":"2010","unstructured":"TD Ashworth, , Deletion-based mechanisms of Notch1 activation in T-ALL: Key roles for RAG recombinase and a conserved internal translational start site in Notch1. Blood 116, 5455\u20135464 (2010).","journal-title":"Blood"},{"key":"e_1_3_4_59_2","doi-asserted-by":"crossref","first-page":"5211","DOI":"10.1182\/blood-2011-10-388504","article-title":"An activating intragenic deletion in NOTCH1 in human T-ALL","volume":"119","author":"Haydu JE","year":"2012","unstructured":"JE Haydu, , An activating intragenic deletion in NOTCH1 in human T-ALL. Blood 119, 5211\u20135214 (2012).","journal-title":"Blood"},{"key":"e_1_3_4_60_2","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/ni.2538","article-title":"Distinct TCR signaling pathways drive proliferation and cytokine production in T cells","volume":"14","author":"Guy CS","year":"2013","unstructured":"CS Guy, , Distinct TCR signaling pathways drive proliferation and cytokine production in T cells. Nat Immunol 14, 262\u2013270 (2013).","journal-title":"Nat Immunol"},{"key":"e_1_3_4_61_2","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.gde.2009.04.005","article-title":"Endocytic regulation of Notch signaling","volume":"19","author":"Fortini ME","year":"2009","unstructured":"ME Fortini, D Bilder, Endocytic regulation of Notch signaling. Curr Opin Genet Dev 19, 323\u2013328 (2009).","journal-title":"Curr Opin Genet Dev"},{"key":"e_1_3_4_62_2","doi-asserted-by":"crossref","first-page":"14902","DOI":"10.1073\/pnas.1108892108","article-title":"Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth","volume":"108","author":"Zhao B","year":"2011","unstructured":"B Zhao, , Epstein-Barr virus exploits intrinsic B-lymphocyte transcription programs to achieve immortal cell growth. Proc Natl Acad Sci USA 108, 14902\u201314907 (2011).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_63_2","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1038\/ng.3470","article-title":"Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers","volume":"48","author":"Zhang X","year":"2016","unstructured":"X Zhang, , Identification of focally amplified lineage-specific super-enhancers in human epithelial cancers. Nat Genet 48, 176\u2013182 (2016).","journal-title":"Nat Genet"},{"key":"e_1_3_4_64_2","doi-asserted-by":"crossref","first-page":"2648","DOI":"10.1101\/gad.232710.113","article-title":"Role of SWI\/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation","volume":"27","author":"Shi J","year":"2013","unstructured":"J Shi, , Role of SWI\/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation. Genes Dev 27, 2648\u20132662 (2013).","journal-title":"Genes Dev"},{"key":"e_1_3_4_65_2","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1182\/blood-2012-09-458265","article-title":"Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia","volume":"121","author":"Rossi D","year":"2013","unstructured":"D Rossi, , Integrated mutational and cytogenetic analysis identifies new prognostic subgroups in chronic lymphocytic leukemia. Blood 121, 1403\u20131412 (2013).","journal-title":"Blood"},{"key":"e_1_3_4_66_2","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1038\/nature08878","article-title":"Therapeutic antibody targeting of individual Notch receptors","volume":"464","author":"Wu Y","year":"2010","unstructured":"Y Wu, , Therapeutic antibody targeting of individual Notch receptors. Nature 464, 1052\u20131057 (2010).","journal-title":"Nature"},{"key":"e_1_3_4_67_2","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/ng1018","article-title":"Acetylation inactivates the transcriptional repressor BCL6","volume":"32","author":"Bereshchenko OR","year":"2002","unstructured":"OR Bereshchenko, W Gu, R Dalla-Favera, Acetylation inactivates the transcriptional repressor BCL6. Nat Genet 32, 606\u2013613 (2002).","journal-title":"Nat Genet"},{"key":"e_1_3_4_68_2","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1073\/pnas.0509969103","article-title":"PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells","volume":"103","author":"Pasqualucci L","year":"2006","unstructured":"L Pasqualucci, Y Kitaura, H Gu, R Dalla-Favera, PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells. Proc Natl Acad Sci USA 103, 395\u2013400 (2006).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_69_2","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/ni.2428","article-title":"The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry","volume":"13","author":"Dominguez-Sola D","year":"2012","unstructured":"D Dominguez-Sola, , The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry. Nat Immunol 13, 1083\u20131091 (2012).","journal-title":"Nat Immunol"},{"key":"e_1_3_4_70_2","doi-asserted-by":"crossref","first-page":"14908","DOI":"10.1073\/pnas.1109023108","article-title":"Genome-wide analysis reveals conserved and divergent features of Notch1\/RBPJ binding in human and murine T-lymphoblastic leukemia cells","volume":"108","author":"Wang H","year":"2011","unstructured":"H Wang, , Genome-wide analysis reveals conserved and divergent features of Notch1\/RBPJ binding in human and murine T-lymphoblastic leukemia cells. Proc Natl Acad Sci USA 108, 14908\u201314913 (2011).","journal-title":"Proc Natl Acad Sci USA"},{"key":"e_1_3_4_71_2","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1038\/nprot.2013.023","article-title":"High-throughput chromatin immunoprecipitation for genome-wide mapping of in vivo protein-DNA interactions and epigenomic states","volume":"8","author":"Blecher-Gonen R","year":"2013","unstructured":"R Blecher-Gonen, , High-throughput chromatin immunoprecipitation for genome-wide mapping of in vivo protein-DNA interactions and epigenomic states. Nat Protoc 8, 539\u2013554 (2013).","journal-title":"Nat Protoc"},{"key":"e_1_3_4_72_2","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead B","year":"2012","unstructured":"B Langmead, SL Salzberg, Fast gapped-read alignment with Bowtie 2. Nat Methods 9, 357\u2013359 (2012).","journal-title":"Nat Methods"},{"key":"e_1_3_4_73_2","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The Sequence Alignment\/Map format and SAMtools","volume":"25","author":"Li H","year":"2009","unstructured":"H Li, , The Sequence Alignment\/Map format and SAMtools. Bioinformatics; 1000 Genome Project Data Processing Subgroup 25, 2078\u20132079 (2009).","journal-title":"Bioinformatics"},{"key":"e_1_3_4_74_2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1186\/1471-2105-12-277","article-title":"An integrated ChIP-seq analysis platform with customizable workflows","volume":"12","author":"Giannopoulou EG","year":"2011","unstructured":"EG Giannopoulou, O Elemento, An integrated ChIP-seq analysis platform with customizable workflows. BMC Bioinformatics 12, 277 (2011).","journal-title":"BMC Bioinformatics"},{"key":"e_1_3_4_75_2","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1093\/bioinformatics\/btr030","article-title":"Identifying dispersed epigenomic domains from ChIP-Seq data","volume":"27","author":"Song Q","year":"2011","unstructured":"Q Song, AD Smith, Identifying dispersed epigenomic domains from ChIP-Seq data. Bioinformatics 27, 870\u2013871 (2011).","journal-title":"Bioinformatics"},{"key":"e_1_3_4_76_2","doi-asserted-by":"crossref","first-page":"5446","DOI":"10.1182\/blood-2007-06-093906","article-title":"Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines","volume":"111","author":"Hallek M","year":"2008","unstructured":"M Hallek, , Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: A report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood; International Workshop on Chronic Lymphocytic Leukemia 111, 5446\u20135456 (2008).","journal-title":"Blood"},{"key":"e_1_3_4_77_2","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method","volume":"25","author":"Livak KJ","year":"2001","unstructured":"KJ Livak, TD Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25, 402\u2013408 (2001).","journal-title":"Methods"},{"key":"e_1_3_4_78_2","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1093\/bioinformatics\/btp120","article-title":"TopHat: Discovering splice junctions with RNA-Seq","volume":"25","author":"Trapnell C","year":"2009","unstructured":"C Trapnell, L Pachter, SL Salzberg, TopHat: Discovering splice junctions with RNA-Seq. Bioinformatics 25, 1105\u20131111 (2009).","journal-title":"Bioinformatics"},{"key":"e_1_3_4_79_2","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/nbt.1621","article-title":"Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation","volume":"28","author":"Trapnell C","year":"2010","unstructured":"C Trapnell, , Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol 28, 511\u2013515 (2010).","journal-title":"Nat Biotechnol"},{"key":"e_1_3_4_80_2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate\u2014A practical and powerful approach to multiple testing","volume":"57","author":"Benjamini YH","year":"1995","unstructured":"YH Benjamini, Controlling the false discovery rate\u2014A practical and powerful approach to multiple testing. J R Stat Soc Series B Stat Methodol 57, 289\u2013300 (1995).","journal-title":"J R Stat Soc Series B Stat Methodol"},{"key":"e_1_3_4_81_2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/nri3814","article-title":"Germinal centres and B cell lymphomagenesis","volume":"15","author":"Basso K","year":"2015","unstructured":"K Basso, R Dalla-Favera, Germinal centres and B cell lymphomagenesis. Nat Rev Immunol 15, 172\u2013184 (2015).","journal-title":"Nat Rev Immunol"},{"key":"e_1_3_4_82_2","doi-asserted-by":"crossref","first-page":"2240","DOI":"10.1182\/blood-2012-03-415380","article-title":"Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas","volume":"120","author":"Victora GD","year":"2012","unstructured":"GD Victora, , Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas. Blood 120, 2240\u20132248 (2012).","journal-title":"Blood"},{"key":"e_1_3_4_83_2","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1038\/sj.leu.2404258","article-title":"CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors","volume":"20","author":"Palomero T","year":"2006","unstructured":"T Palomero, , CUTLL1, a novel human T-cell lymphoma cell line with t(7;9) rearrangement, aberrant NOTCH1 activation and high sensitivity to gamma-secretase inhibitors. Leukemia 20, 1279\u20131287 (2006).","journal-title":"Leukemia"},{"key":"e_1_3_4_84_2","doi-asserted-by":"crossref","first-page":"D164","DOI":"10.1093\/nar\/gkv1002","article-title":"dbSUPER: A database of super-enhancers in mouse and human genome","volume":"44","author":"Khan A","year":"2016","unstructured":"A Khan, X Zhang, dbSUPER: A database of super-enhancers in mouse and human genome. Nucleic Acids Res 44, D164\u2013D171 (2016).","journal-title":"Nucleic Acids Res"}],"container-title":["Proceedings of the National Academy of Sciences"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/www.pnas.org\/syndication\/doi\/10.1073\/pnas.1702564114","content-type":"unspecified","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/pnas.org\/doi\/pdf\/10.1073\/pnas.1702564114","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,22]],"date-time":"2024-06-22T23:01:15Z","timestamp":1719097275000},"score":1,"resource":{"primary":{"URL":"https:\/\/pnas.org\/doi\/full\/10.1073\/pnas.1702564114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,3,17]]},"references-count":84,"journal-issue":{"issue":"14","published-print":{"date-parts":[[2017,4,4]]}},"alternative-id":["10.1073\/pnas.1702564114"],"URL":"https:\/\/doi.org\/10.1073\/pnas.1702564114","relation":{},"ISSN":["0027-8424","1091-6490"],"issn-type":[{"value":"0027-8424","type":"print"},{"value":"1091-6490","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,3,17]]},"assertion":[{"value":"2017-03-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}