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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,10,3]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>The interplay between microRNAs and the cell-cycle machinery in vivo remains poorly understood. Here we report that the microRNA family miR-34\/449 plays an essential and rate-limiting role in repressing cell-cycle proteins and enforcing cell-cycle exit during epithelial cell differentiation. We demonstrate that genetic ablation of the entire miR-34\/449 family leads to derepression of cell cycle-promoting proteins in differentiating epithelial cells, thereby preventing their timely cell-cycle exit. This, in turn, impairs epithelial ciliation and leads to profound developmental defects. Hence, this study describes a function of the miR-34\/449 family in linking cell proliferation and differentiation.<\/jats:p>","DOI":"10.1073\/pnas.1702914114","type":"journal-article","created":{"date-parts":[[2017,9,18]],"date-time":"2017-09-18T21:00:20Z","timestamp":1505768420000},"page":"10660-10665","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":93,"title":["Cell cycle-targeting microRNAs promote differentiation by enforcing cell-cycle exit"],"prefix":"10.1073","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5594-3055","authenticated-orcid":false,"given":"Tobias","family":"Otto","sequence":"first","affiliation":[{"name":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheyla V.","family":"Candido","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary S.","family":"Pilarz","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Sicinska","sequence":"additional","affiliation":[{"name":"Department of Oncologic Pathology, Dana-Farber Cancer Institute, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roderick T.","family":"Bronson","sequence":"additional","affiliation":[{"name":"Rodent Histopathology Core, Dana-Farber\/Harvard Cancer Center, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Bowden","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iga A.","family":"Lachowicz","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Mulry","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Fassl","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard C.","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuelle S.","family":"Jecrois","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Sicinski","sequence":"additional","affiliation":[{"name":"Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215;"},{"name":"Department of Genetics, Harvard Medical School, Boston, MA 02115;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,9,18]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: Target recognition and regulatory functions","volume":"136","author":"Bartel DP","year":"2009","unstructured":"DP Bartel, MicroRNAs: Target recognition and regulatory functions. 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