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U.S.A."],"published-print":{"date-parts":[[2017,5,23]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>Cerebral cavernous malformations (CCMs) are common vascular anomalies of the central nervous system that can lead to seizures, focal neurological deficits, and brain hemorrhage. Clinical options are limited mainly to treatment of symptoms or surgical resection, and targeted pharmacological therapy is lacking. Here we undertake a high-throughput screen and identify fluvastatin and zoledronate, two drugs already approved for clinical use for other indications, which act synergistically to reverse outcomes of CCM3 loss. Used in combination, fluvastatin and zoledronate effectively attenuate neural and vascular deficits in mouse models of CCM in vivo, significantly reducing formation of lesions and extending longevity. 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