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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,5,2]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Ca\n                    <jats:sup>2<\/jats:sup>\n                    <jats:sup>+<\/jats:sup>\n                    - and voltage-regulated K\n                    <jats:sup>+<\/jats:sup>\n                    channels (termed BK channels) are expressed in a diverse variety of cells, playing distinct physiological roles often defined by cell-specific regulatory subunits. Here, genetic deletion of one particular regulatory subunit, LRRC26, reveals that LRRC26-containing BK channels are found, perhaps exclusively, in secretory epithelial cells, including salivary glands, airways, and gastrointestinal tract. Such cells mediate fluid, peptide, and mucus secretion, influencing digestion, airway function, gut resistance to infection, and lactation. The absence of LRRC26 in secretory epithelial cells renders BK channels inactive during normal physiological conditions and alters ion efflux from salivary gland. LRRC26-containing BK channels are critical for normal ionic flux in secretory epithelial cells, likely impacting on a variety of epithelial cell pathologies.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1703081114","type":"journal-article","created":{"date-parts":[[2017,4,17]],"date-time":"2017-04-17T20:50:22Z","timestamp":1492462222000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":38,"title":["Knockout of the LRRC26 subunit reveals a primary role of LRRC26-containing BK channels in secretory epithelial cells"],"prefix":"10.1073","volume":"114","author":[{"given":"Chengtao","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Washington University School of Medicine, St. Louis, MO 63110;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Gonzalez-Perez","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Washington University 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