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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,6,27]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    T cells are required for control of many intracellular infections, and a critical component of T cell immunity is the proliferative expansion of effector T cells upon stimulation. Using a forward-based genetic screen, we identify the mouse\n                    <jats:italic>Etaa1<\/jats:italic>\n                    gene as critically important for T cell proliferative expansion after vaccination and during infection. Consistent with recent findings that ETAA1 prevents DNA damage during proliferation, our data demonstrate elevated DNA damage within\n                    <jats:italic>Etaa1<\/jats:italic>\n                    -deficient effector T cells, which likely leads to cell death. This phenotype is restricted to effector T cell proliferation, with T cell development and other immune parameters remaining normal. Thus, ETAA1 may represent a novel drug target to selectively suppress pathological T cell responses in transplantation or autoimmunity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1705795114","type":"journal-article","created":{"date-parts":[[2017,6,12]],"date-time":"2017-06-12T20:50:28Z","timestamp":1497300628000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":20,"title":["Systems-guided forward genetic screen reveals a critical role of the replication stress response protein ETAA1 in T cell clonal expansion"],"prefix":"10.1073","volume":"114","author":[{"given":"Lisa A.","family":"Miosge","sequence":"first","affiliation":[{"name":"John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yovina","family":"Sontani","sequence":"additional","affiliation":[{"name":"John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Chuah","sequence":"additional","affiliation":[{"name":"John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Horikawa","sequence":"additional","affiliation":[{"name":"John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany A.","family":"Russell","sequence":"additional","affiliation":[{"name":"John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Mei","sequence":"additional","affiliation":[{"name":"John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayura V.","family":"Wagle","sequence":"additional","affiliation":[{"name":"John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie R.","family":"Howard","sequence":"additional","affiliation":[{"name":"John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anselm","family":"Enders","sequence":"additional","affiliation":[{"name":"John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Tscharke","sequence":"additional","affiliation":[{"name":"John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher C.","family":"Goodnow","sequence":"additional","affiliation":[{"name":"John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia;"},{"name":"Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia;"},{"name":"St. Vincent\u2019s Clinical School, University of New South Wales, Darlinghurst, New South Wales 2010, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian A.","family":"Parish","sequence":"additional","affiliation":[{"name":"John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601, Australia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,6,12]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1128\/JVI.01459-06","article-title":"Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: It is even bigger than we thought","volume":"81","author":"Masopust D","year":"2007","unstructured":"D Masopust, K Murali-Krishna, R Ahmed, Quantitating the magnitude of the lymphocytic choriomeningitis virus-specific CD8 T-cell response: It is even bigger than we thought. 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