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Here, we demonstrate that\n                    <jats:italic>Egr1<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice on the C57BL\/6 background have normal eyelid development, but back-crossing to BALB\/c background for four or five generations resulted in defective eyelid development by embryonic day E15.5. This defective eyelid formation was then further associated with profound ocular anomalies evident by postnatal days 1-4. The BALB\/c albino phenotype associated with the\n                    <jats:italic>Tyr<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>c<\/jats:italic>\n                    <\/jats:sup>\n                    tyrosinase mutation also appeared to contribute to the phenotype. Thus EGR1 in a genetic background-dependent manner plays a critical role in mammalian eyelid development, with subsequent impact on ocular integrity.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1705848114","type":"journal-article","created":{"date-parts":[[2017,8,4]],"date-time":"2017-08-04T21:00:28Z","timestamp":1501880428000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":8,"title":["Genetic background-dependent role of\n                    <i>Egr1<\/i>\n                    for eyelid development"],"prefix":"10.1073","volume":"114","author":[{"given":"Jangsuk","family":"Oh","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892;"},{"name":"Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shida","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892;"},{"name":"Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Du","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892;"},{"name":"Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zu-Xi","family":"Yu","sequence":"additional","affiliation":[{"name":"Pathology Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donna","family":"Butcher","sequence":"additional","affiliation":[{"name":"Pathology\/Histotechnology Laboratory, Leidos Biomedical Research, Inc., Frederick, MD 21702;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tesfay","family":"Gebregiorgis","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Immunology, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892;"},{"name":"Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Strachan","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of Alberta, Edmonton AB, Canada T6G 2H7;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ordan J.","family":"Lehmann","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics, University of Alberta, Edmonton AB, Canada T6G 2H7;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian 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Invest Ophthalmol Vis Sci 47, 1938\u20131946 (2006).","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_3_4_25_2","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jprot.2013.05.023","article-title":"The keratoconus corneal proteome: Loss of epithelial integrity and stromal degeneration","volume":"87","author":"Chaerkady R","year":"2013","unstructured":"R Chaerkady, , The keratoconus corneal proteome: Loss of epithelial integrity and stromal degeneration. J Proteomics 87, 122\u2013131 (2013).","journal-title":"J Proteomics"},{"key":"e_1_3_4_26_2","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1126\/science.1080095","article-title":"Modification of ocular defects in mouse developmental glaucoma models by tyrosinase","volume":"299","author":"Libby RT","year":"2003","unstructured":"RT Libby, , Modification of ocular defects in mouse developmental glaucoma models by tyrosinase. 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Nat Genet 12, 212\u2013215 (1996).","journal-title":"Nat Genet"},{"key":"e_1_3_4_38_2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0014-4835(05)80124-1","article-title":"Biochemical evidence for adhesion-promoting role of major intrinsic protein isolated from both normal and cataractous human lenses","volume":"61","author":"Michea LF","year":"1995","unstructured":"LF Michea, D Andrinolo, H Ceppi, N Lagos, Biochemical evidence for adhesion-promoting role of major intrinsic protein isolated from both normal and cataractous human lenses. Exp Eye Res 61, 293\u2013301 (1995).","journal-title":"Exp Eye Res"},{"key":"e_1_3_4_39_2","first-page":"5","article-title":"Identification of a mutation in the MP19 gene, Lim2, in the cataractous mouse mutant To3","volume":"3","author":"Steele EC","year":"1997","unstructured":"Jr EC Steele, , Identification of a mutation in the MP19 gene, Lim2, in the cataractous mouse mutant To3. 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