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Cells mutated for\n                    <jats:italic>VAC14<\/jats:italic>\n                    displayed increased\n                    <jats:italic>S<\/jats:italic>\n                    . Typhi docking due to increased plasma membrane cholesterol levels. The same SNP was associated with risk of typhoid fever in a Vietnamese population. Furthermore, treating zebrafish with a cholesterol-lowering drug reduced their susceptibility to\n                    <jats:italic>S<\/jats:italic>\n                    . Typhi infection. Therefore, this work demonstrates the power of coupling multiple genetic association studies with mechanistic dissection for understanding infectious disease susceptibility.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1706070114","type":"journal-article","created":{"date-parts":[[2017,8,21]],"date-time":"2017-08-21T20:40:20Z","timestamp":1503348020000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":48,"title":["Human genetic variation in\n                    <i>VAC14<\/i>\n                    regulates\n                    <i>Salmonella<\/i>\n                    invasion and typhoid fever through modulation of cholesterol"],"prefix":"10.1073","volume":"114","author":[{"given":"Monica I.","family":"Alvarez","sequence":"first","affiliation":[{"name":"Department of Molecular Genetics and Microbiology, School of Medicine, Duke University, Durham, NC 27710;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luke 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