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In this work, we performed structural and phylogenic analyses on the fusogenic glycoproteins of Thogoto and Dhori viruses, two representatives of the\n                    <jats:italic>Thogotovirus<\/jats:italic>\n                    genus that cause severe human infections. Previous studies have shown that thogotovirus glycoproteins share \u223c28% sequence identity with baculovirus Gp64s. Our structural analysis confirmed their homology in evolution and identified them as class III viral fusogens, in contrast to class I members of influenza viruses. Our studies provide structural evidence to help us to understand the evolution of these viruses and indicate a potential target for antiviral drug design.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1706125114","type":"journal-article","created":{"date-parts":[[2017,10,4]],"date-time":"2017-10-04T21:05:13Z","timestamp":1507151113000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":40,"title":["Structures of human-infecting\n                    <i>Thogotovirus<\/i>\n                    fusogens support a common ancestor with insect baculovirus"],"prefix":"10.1073","volume":"114","author":[{"given":"Ruchao","family":"Peng","sequence":"first","affiliation":[{"name":"Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;"},{"name":"School of Life Sciences, University of Chinese Academy of Sciences, Beijing 101408, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuijun","family":"Zhang","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzi","family":"Cui","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;"},{"name":"School of Life Sciences, University of Chinese Academy of Sciences, Beijing 101408, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Shi","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;"},{"name":"School of Life Sciences, University of Chinese Academy of Sciences, Beijing 101408, China;"},{"name":"Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People\u2019s Hospital, Shenzhen 518112, China;"},{"name":"Center for Influenza Research and Early-Warning, Chinese Academy of Sciences, Beijing 100101, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3869-615X","authenticated-orcid":false,"given":"George F.","family":"Gao","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;"},{"name":"School of Life Sciences, University of Chinese Academy of Sciences, Beijing 101408, China;"},{"name":"Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People\u2019s Hospital, Shenzhen 518112, China;"},{"name":"Center for Influenza Research and Early-Warning, Chinese Academy of Sciences, Beijing 100101, China;"},{"name":"National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxun","family":"Qi","sequence":"additional","affiliation":[{"name":"Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China;"},{"name":"School of Life Sciences, University of Chinese Academy of Sciences, Beijing 101408, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,10,4]]},"reference":[{"key":"e_1_3_4_1_2","first-page":"681","volume-title":"Virus Taxonomy: Eighth Report of the International Committee on Taxonomy of Viruses","author":"Kawaoka Y","year":"2005","unstructured":"Y Kawaoka, P Palese, Family Orthomyxoviridae. 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