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We demonstrate that phosphorylation of HRC at Ser96 indeed provides protection from heart disease, and we identify family with sequence similarity 20C (Fam20C) as the kinase that phosphorylates HRC. HRC phosphorylation appears to play a role in regulating Ca cycling that is critical for proper cardiac muscle contraction. This demonstration of Fam20C\u2019s role in heart disease opens up avenues for potential preventative or therapeutic strategies.<\/jats:p>","DOI":"10.1073\/pnas.1706441114","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T10:10:52Z","timestamp":1502187052000},"page":"9098-9103","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":41,"title":["Phosphorylation of serine96 of histidine-rich calcium-binding protein by the Fam20C kinase functions to prevent cardiac arrhythmia"],"prefix":"10.1073","volume":"114","author":[{"given":"Adam J.","family":"Pollak","sequence":"first","affiliation":[{"name":"Department of Pharmacology, University of California, San Diego, La Jolla, CA 92093;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kobra","family":"Haghighi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Cell Biophysics, University of Cincinnati College of 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