{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T21:06:23Z","timestamp":1783631183660,"version":"3.55.0"},"reference-count":49,"publisher":"National Academy of Sciences","issue":"34","content-domain":{"domain":["www.pnas.org"],"crossmark-restriction":true},"short-container-title":["Proc. Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,8,22]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Aberrant inflammation is the root cause of numerous human diseases, from autoimmunity to cancer.\n                    <jats:italic>microRNA-146a<\/jats:italic>\n                    (\n                    <jats:italic>miR-146a<\/jats:italic>\n                    ), a member of a large class of small regulatory RNAs, functions as a critical molecular brake on inflammation and malignant transformation. However, the molecular mechanism through which\n                    <jats:italic>miR-146a<\/jats:italic>\n                    exerts its regulatory activity in immune cells is unclear. Using mouse genetics, we have examined the role of the\n                    <jats:italic>miR-146a\u2013Traf6<\/jats:italic>\n                    signaling axis and found that although this miRNA\u2013target interaction is responsible for regulating normal myeloid cell development and autoimmunity, it is dispensable for hematopoietic stem cell homeostasis and tumor suppression.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1706833114","type":"journal-article","created":{"date-parts":[[2017,8,8]],"date-time":"2017-08-08T10:10:52Z","timestamp":1502187052000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":58,"title":["<i>miR-146a<\/i>\n                    \u2013\n                    <i>Traf6<\/i>\n                    regulatory axis controls autoimmunity and myelopoiesis, but is dispensable for hematopoietic stem cell homeostasis and tumor suppression"],"prefix":"10.1073","volume":"114","author":[{"given":"Nathaniel","family":"Magilnick","sequence":"first","affiliation":[{"name":"Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope, Duarte, CA 91010;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefany Y.","family":"Reyes","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope, Duarte, CA 91010;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Le","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Biology, Beckman Research Institute, City of Hope, Duarte, CA 91010;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L.","family":"Vonderfecht","sequence":"additional","affiliation":[{"name":"Division of Comparative Medicine, Beckman Research Institute, City of Hope, Duarte, CA 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