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U.S.A."],"published-print":{"date-parts":[[2017,10,24]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Apoptotic morphogenesis requires strict regulation as both excessive and insufficient cell death is detrimental to tissue function. Here we use the process of ureter maturation, wherein the ureter connects to the bladder by the apoptosis-mediated removal of the intervening common nephric duct (CND), to investigate this paradigm. We find that LAR family phosphatases antagonize cIAP1 activity by decreasing its stability, thereby releasing the brake on CND elimination. In addition, we demonstrate that\n                    <jats:italic>Birc2<\/jats:italic>\n                    (cIAP1) mutant embryos exhibit increased CND apoptosis, leading to accelerated ureter maturation and vesicoureteral reflux. Together this highlights the importance of modulating the rate of apoptosis during morphogenesis, which may act as a morphogenetic timer to allow for appropriate tissue rearrangements during embryonic development.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1707229114","type":"journal-article","created":{"date-parts":[[2017,10,9]],"date-time":"2017-10-09T15:00:08Z","timestamp":1507561208000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":6,"title":["Modulation of apoptotic response by LAR family phosphatases\u2013cIAP1 signaling during urinary tract morphogenesis"],"prefix":"10.1073","volume":"114","author":[{"given":"Katherine","family":"Stewart","sequence":"first","affiliation":[{"name":"Department of Biochemistry, McGill University, Montreal, QC, Canada H3G 1Y6;"},{"name":"Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada H3A 1A3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You Chi","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, McGill University, Montreal, QC, Canada H3G 1Y6;"},{"name":"Goodman Cancer Research Centre, McGill University, Montreal, QC, Canada H3A 1A3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxwell E. 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