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These important findings highlight the significant impacts that B cell-specific IL-4R\u03b1 and IL-4 responsiveness have in the context of type 1 (\n                    <jats:italic>L. major<\/jats:italic>\n                    ) and type 2 (\n                    <jats:italic>S. mansoni<\/jats:italic>\n                    ) pathogens. Thus, vaccine and therapeutic development should aim to target both B and T cell immunity for optimal efficacy.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1708125114","type":"journal-article","created":{"date-parts":[[2017,9,15]],"date-time":"2017-09-15T21:20:20Z","timestamp":1505510420000},"update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":36,"title":["IL-4\u2013producing B cells regulate T helper cell dichotomy in type 1- and type 2-controlled diseases"],"prefix":"10.1073","volume":"114","author":[{"given":"Ramona","family":"Hurdayal","sequence":"first","affiliation":[{"name":"Institute of Infectious Diseases and Molecular Medicine (IDM), Division of Immunology and South African Medical Research Council (SAMRC), Immunology of Infectious Diseases, Faculty of Health Sciences, University of Cape Town, Cape Town 7925, South Africa;"},{"name":"International Center for Genetic Engineering and Biotechnology (ICGEB), Cape Town 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