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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2019,11,19]]},"abstract":"<jats:p>\n                    The plant circadian clock evolved to increase fitness by synchronizing physiological processes with environmental oscillations. Crop fitness was artificially selected through domestication and breeding, and the circadian clock was identified by both natural and artificial selections as a key to improved fitness. Despite progress in\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    , our understanding of the crop circadian clock is still limited, impeding its rational improvement for enhanced fitness. To unveil the interactions between the crop circadian clock and various environmental cues, we comprehensively mapped abiotic stress inputs to the soybean circadian clock using a 2-module discovery pipeline. Using the \u201cmolecular timetable\u201d method, we computationally surveyed publicly available abiotic stress-related soybean transcriptomes to identify stresses that have strong impacts on the global rhythm. These findings were then experimentally confirmed using a multiplexed RNA sequencing technology. Specific clock components modulated by each stress were further identified. This comprehensive mapping uncovered inputs to the plant circadian clock such as alkaline stress. Moreover, short-term iron deficiency targeted different clock components in soybean and\n                    <jats:italic>Arabidopsis<\/jats:italic>\n                    and thus had opposite effects on the clocks of these 2 species. Comparing soybean varieties with different iron uptake efficiencies suggests that phase modulation might be a mechanism to alleviate iron deficiency symptoms in soybean. These unique responses in soybean demonstrate the need to directly study crop circadian clocks. Our discovery pipeline may serve as a broadly applicable tool to facilitate these explorations.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1708508116","type":"journal-article","created":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T19:49:06Z","timestamp":1572637746000},"page":"23840-23849","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":62,"title":["Comprehensive mapping of abiotic stress inputs into the soybean circadian clock"],"prefix":"10.1073","volume":"116","author":[{"given":"Meina","family":"Li","sequence":"first","affiliation":[{"name":"School of Life Sciences, Guangzhou University, 510006 Guangzhou, China;"},{"name":"Department of Plant Pathology and Microbiology, Iowa State University, Ames, IA 50011;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijun","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology and Microbiology, Iowa State University, Ames, IA 50011;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Musoki","family":"Mwimba","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Gordon and Betty Moore Foundation, Duke University, Durham, NC 27708;"},{"name":"Department of Biology, Duke University, Durham, NC 27708;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Agronomy, Iowa State University, Ames, IA 50011;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2371-6215","authenticated-orcid":false,"given":"Ling","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Mississippi State University, Starkville, MS 39762;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology and Microbiology, Iowa State University, Ames, IA 50011;"},{"name":"College of Life Sciences, Capital Normal University, 100048 Beijing, China;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9169-5204","authenticated-orcid":false,"given":"Patrick S.","family":"Schnable","sequence":"additional","affiliation":[{"name":"Department of Agronomy, Iowa State University, Ames, IA 50011;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2403-8946","authenticated-orcid":false,"given":"Jamie A.","family":"O\u2019Rourke","sequence":"additional","affiliation":[{"name":"Department of Agronomy, Iowa State University, Ames, IA 50011;"},{"name":"Corn Insects and Crop Genetics Research Unit, Agricultural Research Service, US Department of Agriculture, Ames, IA 50011;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1120-0951","authenticated-orcid":false,"given":"Xinnian","family":"Dong","sequence":"additional","affiliation":[{"name":"Howard Hughes Medical Institute and Gordon and Betty Moore Foundation, Duke University, Durham, NC 27708;"},{"name":"Department of Biology, Duke University, Durham, NC 27708;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Plant Pathology and Microbiology, Iowa State University, Ames, IA 50011;"},{"name":"State Key Laboratory for Protein and Plant Gene Research, School of Life Sciences, Peking University, 100871 Beijing, China;"},{"name":"Peking-Tsinghua Center for Life Sciences, 100871 Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2019,11]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/nrg3976","article-title":"Integrating circadian dynamics with physiological processes in plants","volume":"16","author":"Greenham K.","year":"2015","unstructured":"K. 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