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Previous studies indicated that disruptions of the TRAF4 interaction with platelet receptors and the TGF-\u03b2 receptor are a potential target for therapeutic intervention by antithrombotic drugs and anticancer drugs, respectively. In this study, we report a crystal structure of TRAF4 in complex with a peptide from the GPIb\u03b2 receptor. The structure revealed a TRAF4-binding motif of Arg\u2013Leu\u2013X\u2013Ala. We also found that the TGF-\u03b2 receptor contains the TRAF4-binding motif and showed a direct interaction between TRAF4 and the receptor. The current structure will provide a template for furthering our understanding of the receptor-binding specificity of TRAF4, TRAF4-mediated signaling, and related diseases.<\/jats:p>","DOI":"10.1073\/pnas.1708688114","type":"journal-article","created":{"date-parts":[[2017,10,10]],"date-time":"2017-10-10T13:40:23Z","timestamp":1507642823000},"page":"11422-11427","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":16,"title":["Molecular basis for unique specificity of human TRAF4 for platelets GPIb\u03b2 and GPVI"],"prefix":"10.1073","volume":"114","author":[{"given":"Chang Min","family":"Kim","sequence":"first","affiliation":[{"name":"School of Natural Science, Department of Chemistry and Biochemistry, Yeungnam University, Gyeongsan 712-749, South Korea;"},{"name":"School of Natural Science, Graduate School of Biochemistry, Yeungnam University, Gyeongsan 712-749, South Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Jin","family":"Son","sequence":"additional","affiliation":[{"name":"New Drug Development Center, Daegu-Gyungpook Medical Innovation Foundation, Daegu 701-310, South Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunghwan","family":"Kim","sequence":"additional","affiliation":[{"name":"New Drug Development Center, Daegu-Gyungpook Medical Innovation Foundation, Daegu 701-310, South Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seo Yun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Pulmonology, Korea Cancer Center Hospital, Seoul 01812, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun Ho","family":"Park","sequence":"additional","affiliation":[{"name":"School of Natural Science, Department of Chemistry and Biochemistry, Yeungnam University, Gyeongsan 712-749, South Korea;"},{"name":"School of Natural Science, Graduate School of Biochemistry, Yeungnam University, Gyeongsan 712-749, South Korea;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"341","published-online":{"date-parts":[[2017,10,10]]},"reference":[{"key":"e_1_3_4_1_2","doi-asserted-by":"crossref","first-page":"1798","DOI":"10.1182\/blood.V96.5.1798","article-title":"Cloning, characterization, and functional studies of human and mouse glycoprotein VI: A platelet-specific collagen receptor from the immunoglobulin superfamily","volume":"96","author":"Jandrot-Perrus M","year":"2000","unstructured":"M Jandrot-Perrus, , Cloning, characterization, and functional studies of human and mouse glycoprotein VI: A platelet-specific collagen receptor from the immunoglobulin superfamily. 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