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U.S.A."],"published-print":{"date-parts":[[2017,10,24]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Mitochondrial calcium uniporter (MCU) is the core channel subunit of the mitochondrial Ca\n                    <jats:sup>2+<\/jats:sup>\n                    uniporter complex (MCUC) and contributes to the regulation of ATP production. Here, we identify that the adaptive and maladaptive remodeling occurring in rodent and human cardiomyocytes is associated with changes in MCU content, which are inversely correlated with those of its regulator microRNA-1 (miR-1). The present study thus defines the molecular mechanism by which MCU content and, consequently, mitochondrial Ca\n                    <jats:sup>2+<\/jats:sup>\n                    uptake are directly modified by alteration of miR-1, a key regulator affecting physiological and pathological heart growth. 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