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Viral transfer of the wild-type cDNA to the inner ear of the mutant mice shortly after birth resulted in a partial restoration of hearing and a long-lasting, almost complete, removal of the balance defect. The present results provide a basis for future clinical trials in humans.<\/jats:p>","DOI":"10.1073\/pnas.1708894114","type":"journal-article","created":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T21:00:45Z","timestamp":1503522045000},"page":"9695-9700","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":134,"title":["Local gene therapy durably restores vestibular function in a mouse model of Usher syndrome type 1G"],"prefix":"10.1073","volume":"114","author":[{"given":"Alice","family":"Emptoz","sequence":"first","affiliation":[{"name":"INSERM, UMR 1120, Paris, France;"},{"name":"G\u00e9n\u00e9tique et Physiologie de l\u2019Audition, Institut Pasteur, 75015 Paris, France;"},{"name":"Complexit\u00e9 du Vivant, Sorbonne Universit\u00e9s, Universit\u00e9 Pierre-et-Marie-Curie, Universit\u00e9 Paris VI, 75015 Paris, 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