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Natl. Acad. Sci. U.S.A."],"published-print":{"date-parts":[[2017,10,24]]},"abstract":"<jats:title>Significance<\/jats:title>\n                  <jats:p>\n                    Chondrodystrophy, characterized by short limbs and intervertebral disc disease (IVDD), is a common phenotype in many of the most popular dog breeds, including the dachshund, beagle, and French bulldog. Here, we report the identification of a\n                    <jats:italic>FGF4<\/jats:italic>\n                    retrogene insertion on chromosome 12, the second\n                    <jats:italic>FGF4<\/jats:italic>\n                    retrogene reported in the dog, as responsible for chondrodystrophy and IVDD. Identification of the causative mutation for IVDD will impact an incredibly large proportion of the dog population and provides a model for IVDD in humans, as FGF-associated mutations are responsible for IVDD and short stature in human achondroplasia. This is a report of a second retrogene copy of the same parental gene, each causing complementary disease phenotypes in a mammalian species.\n                  <\/jats:p>","DOI":"10.1073\/pnas.1709082114","type":"journal-article","created":{"date-parts":[[2017,10,11]],"date-time":"2017-10-11T15:25:13Z","timestamp":1507735513000},"page":"11476-11481","update-policy":"https:\/\/doi.org\/10.1073\/pnas.cm10313","source":"Crossref","is-referenced-by-count":141,"title":["<i>FGF4<\/i>\n                    retrogene on CFA12 is responsible for chondrodystrophy and intervertebral disc disease in dogs"],"prefix":"10.1073","volume":"114","author":[{"given":"Emily A.","family":"Brown","sequence":"first","affiliation":[{"name":"Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Dickinson","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tamer","family":"Mansour","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beverly K.","family":"Sturges","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Aguilar","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4181-4233","authenticated-orcid":false,"given":"Amy E.","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Courtney","family":"Korff","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Lind","sequence":"additional","affiliation":[{"name":"Department of Population Health and Reproduction, School of Veterinary Medicine, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cassandra L.","family":"Ettinger","sequence":"additional","affiliation":[{"name":"Genome Center, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Varon","sequence":"additional","affiliation":[{"name":"Barney and Russum Animal Clinic, Fairfield, CA 94533;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Pollard","sequence":"additional","affiliation":[{"name":"Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California, Davis, CA 95616;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. 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